Imprinting disorders and assisted reproductive technology

Lawrence N. Odom, James Segars

Research output: Contribution to journalArticle

Abstract

Purpose Of Review: To summarize current evidence in the association of imprinting disorders and assisted reproductive technology. Recent Findings: The worldwide usage of assisted reproductive technology (ART) has continued to increase since the first successful birth of a human after IVF. Since 2002, several reports have raised concerns that children conceived by ART are at increased risk of having imprinting disorders. The majority of published studies have examined DNA methylation in children conceived by ART, but results are conflicting. Beckwithĝ€"Wiedemann syndrome and Angelman syndrome are the most extensively studied imprinting disorders and multiple case series and reports have been published on ART-conceived children with these syndromes. Overall the majority of reports suggest that ART might be associated with Beckwithĝ€"Wiedermann syndrome and Angelman syndrome, but larger collaborative studies need to be performed. Summary: The current data suggest an association between imprinting disorders and ART although the absolute risk appears to be low. However, animal studies have established biologic plausibility and there is continuing concern about the possibility of epigenetic changes resulting from ART.

Original languageEnglish (US)
Pages (from-to)517-522
Number of pages6
JournalCurrent Opinion in Endocrinology, Diabetes and Obesity
Volume17
Issue number6
DOIs
StatePublished - Dec 2010
Externally publishedYes

Fingerprint

Assisted Reproductive Techniques
Angelman Syndrome
Beckwith-Wiedemann Syndrome
Birth Order
Imprinting (Psychology)
DNA Methylation
Epigenomics

Keywords

  • Angelman syndrome
  • assisted reproductive technology
  • Beckwith-Wiedemann syndrome
  • DNA methylation
  • imprinting disorders

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine
  • Nutrition and Dietetics

Cite this

Imprinting disorders and assisted reproductive technology. / Odom, Lawrence N.; Segars, James.

In: Current Opinion in Endocrinology, Diabetes and Obesity, Vol. 17, No. 6, 12.2010, p. 517-522.

Research output: Contribution to journalArticle

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