Impression cytology detects sublinical vitamin A deficiency

O. Amedee-Manesme, R. Luzeau, J. R. Wittepen, A. Hanck, A. Sommer

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


The vitamin A status of 16 children with normal eyes and liver disease was evaluated by plasma retinol concentration and by liver vitamin A concentration or iv relative-dose-response-test. Conjunctival impression cytology was performed on each child. All children with normal vitamin A status had normal conjunctival impression cytology. All children with abnormal vitamin A status had abnormal conjunctival impression cytology despite their seemingly normal clinical ocular examination. These results suggest that impression cytology can identify individuals with physiologically significant, preclinical vitamin A deficiency.

Original languageEnglish (US)
Pages (from-to)875-878
Number of pages4
JournalAmerican Journal of Clinical Nutrition
Issue number5
StatePublished - 1988
Externally publishedYes

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


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