Importance of Tumor Location in Patients With High Preoperative Prostate Specific Antigen Levels (Greater Than 20 ng/ml) Treated With Radical Prostatectomy

Ahmed Magheli, Soroush Rais-Bahrami, Hugh J. Peck, Patrick Walsh, Jonathan Ira Epstein, Bruce Trock, Mark L. Gonzalgo

Research output: Contribution to journalArticle


Purpose: We investigated the effect of tumor location (anterior vs posterior) on pathological characteristics and biochemical-free survival in patients with a preoperative prostate specific antigen level of greater than 20 ng/ml undergoing radical prostatectomy since transition zone tumors are known to present with higher prostate specific antigen levels. Materials and Methods: We retrospectively studied the records of 265 patients treated with radical prostatectomy between 1984 and 2005 who had preoperative prostate specific antigen levels greater than 20 ng/ml. Review of pathology reports was performed and tumor location (anterior vs posterior) was defined. Differences in clinicopathological characteristics and prostate specific antigen recurrence rates were examined. Results: Of 265 patients with a preoperative prostate specific antigen level of greater than 20 ng/ml who underwent radical prostatectomy 50 (19%) had anterior tumors and 215 (81%) had posterior tumors. Patients with anterior tumors had lower clinical stage and less seminal vesicle involvement than patients with posterior tumors (p = 0.006 and

Original languageEnglish (US)
Pages (from-to)1311-1315
Number of pages5
JournalJournal of Urology
Issue number4
StatePublished - Oct 2007



  • local
  • neoplasm recurrence
  • prostate
  • prostate-specific antigen
  • prostatectomy
  • prostatic neoplasms

ASJC Scopus subject areas

  • Urology

Cite this