Importance of immunoglobulin heavy chain variable region mutational status in del(13q) chronic lymphocytic leukemia

Douglas Gladstone, Lode Swinnen, Yvette Kasamon, Amanda Blackford, Christopher Gocke, Constance A. Griffin, F Javier Bolanos Meade, Richard J Jones

Research output: Contribution to journalArticle

Abstract

Among prognostic factors for chronic lymphocytic leukemia (CLL), immunoglobulin heavy chain variable region (IGHV) mutation status and DNA analysis appear to be the most important. However, there is limited clinical outcome information for patients with the favorable-risk del(13q) and poor-risk unmutated IGHV. We retrospectively screened all patients with CLL at our institution between 2004 and June 2010 for del(13q) who also had an IGHV analysis. Unmutated IGHV was found in 38/79 patients; age, Rai stage, prior therapy, and time to evaluation were similar to those for patients with mutated IGHV. Unmutated patients were nearly four times more likely to harbor additional chromosomal aberrations compared to mutated patients (p

Original languageEnglish (US)
Pages (from-to)1873-1881
Number of pages9
JournalLeukemia and Lymphoma
Volume52
Issue number10
DOIs
StatePublished - Oct 2011

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Immunoglobulin Heavy Chains
B-Cell Chronic Lymphocytic Leukemia
Chromosome Aberrations
Mutation
DNA

Keywords

  • clinical outcomes
  • CLL
  • del(13q)
  • IGHV
  • overall survival

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Importance of immunoglobulin heavy chain variable region mutational status in del(13q) chronic lymphocytic leukemia. / Gladstone, Douglas; Swinnen, Lode; Kasamon, Yvette; Blackford, Amanda; Gocke, Christopher; Griffin, Constance A.; Bolanos Meade, F Javier; Jones, Richard J.

In: Leukemia and Lymphoma, Vol. 52, No. 10, 10.2011, p. 1873-1881.

Research output: Contribution to journalArticle

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