Importance of cytokines in murine allergic airway disease and human asthma

Fred D. Finkelman, Simon P. Hogan, Gurjit K. Khurana Hershey, Marc E. Rothenberg, Marsha Wills-Karp

Research output: Contribution to journalReview articlepeer-review

Abstract

Asthma is a common, disabling inflammatory respiratory disease that has increased in frequency and severity in developed nations. We review studies of murine allergic airway disease (MAAD) and human asthma that evaluate the importance of Th2 cytokines, Th2 responsepromoting cytokines, IL-17, and proinflammatory and anti-inflammatory cytokines in MAAD and human asthma. We discuss murine studies that directly stimulate airways with specific cytokines or delete, inactivate, neutralize, or block specific cytokines or their receptors, as well as controversial issues including the roles of IL-5, IL-17, and IL-13Rα2 in MAAD and IL-4Rα expression by specific cell types. Studies of human asthmatic cytokine gene and protein expression, linkage of cytokine polymorphisms to asthma, cytokine responses to allergen stimulation, and clinical responses to cytokine antagonists are discussed as well. Results of these analyses establish the importance of specific cytokines in MAAD and human asthma and have therapeutic implications.

Original languageEnglish (US)
Pages (from-to)1663-1674
Number of pages12
JournalJournal of Immunology
Volume184
Issue number4
DOIs
StatePublished - Feb 15 2010
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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