TY - JOUR
T1 - Importance of AMPA receptors for hippocampal synaptic plasticity but not for spatial learning
AU - Zamanillo, Daniel
AU - Sprengel, Rolf
AU - Hvalby, Øivind
AU - Jensen, Vidar
AU - Burnashev, Nail
AU - Rozov, Andrei
AU - Kaiser, Katharina M.M.
AU - Köster, Helmut J.
AU - Borchardt, Thilo
AU - Worley, Paul
AU - Lübke, Joachim
AU - Frotscher, Michael
AU - Kelly, Peter H.
AU - Sommer, Bernd
AU - Andersen, Per
AU - Seeburg, Peter H.
AU - Sakmann, Bert
PY - 1999/6/11
Y1 - 1999/6/11
N2 - Gene-targeted mice lacking the L-α-amino-3-hydroxy-5-methylisoxazole- 4-propionate (AMPA) receptor subunit GluR-A exhibited normal development, life expectancy, and fine structure of neuronal dendrites and synapses. In hippocampal CA1 pyramidal neurons, GluR-A(-/-) mice showed a reduction in functional AMPA receptors, with the remaining receptors preferentially targeted to synapses. Thus, the CA1 soma-patch currents were strongly reduced, but glutamatergic synaptic currents were unaltered: and evoked dendritic and spinous Ca2+ transients, Ca2+-dependent gene activation, and hippocampal field potentials were as in the wild type. In adult GluR-A(- /-) mice, associative long-term potentiation (LTP) was absent in CA3 to CA1 synapses, but spatial learning in the water maze was not impaired. The results suggest that CA1 hippocampal LTP is controlled by the number or subunit composition of AMPA receptors and show a dichotomy between LTP in CA1 and acquisition of spatial memory.
AB - Gene-targeted mice lacking the L-α-amino-3-hydroxy-5-methylisoxazole- 4-propionate (AMPA) receptor subunit GluR-A exhibited normal development, life expectancy, and fine structure of neuronal dendrites and synapses. In hippocampal CA1 pyramidal neurons, GluR-A(-/-) mice showed a reduction in functional AMPA receptors, with the remaining receptors preferentially targeted to synapses. Thus, the CA1 soma-patch currents were strongly reduced, but glutamatergic synaptic currents were unaltered: and evoked dendritic and spinous Ca2+ transients, Ca2+-dependent gene activation, and hippocampal field potentials were as in the wild type. In adult GluR-A(- /-) mice, associative long-term potentiation (LTP) was absent in CA3 to CA1 synapses, but spatial learning in the water maze was not impaired. The results suggest that CA1 hippocampal LTP is controlled by the number or subunit composition of AMPA receptors and show a dichotomy between LTP in CA1 and acquisition of spatial memory.
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U2 - 10.1126/science.284.5421.1805
DO - 10.1126/science.284.5421.1805
M3 - Article
C2 - 10364547
AN - SCOPUS:0033546059
SN - 0036-8075
VL - 284
SP - 1805
EP - 1811
JO - Science
JF - Science
IS - 5421
ER -