Importance of AMPA receptors for hippocampal synaptic plasticity but not for spatial learning

Daniel Zamanillo, Rolf Sprengel, Øivind Hvalby, Vidar Jensen, Nail Burnashev, Andrei Rozov, Katharina M.M. Kaiser, Helmut J. Köster, Thilo Borchardt, Paul Worley, Joachim Lübke, Michael Frotscher, Peter H. Kelly, Bernd Sommer, Per Andersen, Peter H. Seeburg, Bert Sakmann

Research output: Contribution to journalArticlepeer-review

Abstract

Gene-targeted mice lacking the L-α-amino-3-hydroxy-5-methylisoxazole- 4-propionate (AMPA) receptor subunit GluR-A exhibited normal development, life expectancy, and fine structure of neuronal dendrites and synapses. In hippocampal CA1 pyramidal neurons, GluR-A(-/-) mice showed a reduction in functional AMPA receptors, with the remaining receptors preferentially targeted to synapses. Thus, the CA1 soma-patch currents were strongly reduced, but glutamatergic synaptic currents were unaltered: and evoked dendritic and spinous Ca2+ transients, Ca2+-dependent gene activation, and hippocampal field potentials were as in the wild type. In adult GluR-A(- /-) mice, associative long-term potentiation (LTP) was absent in CA3 to CA1 synapses, but spatial learning in the water maze was not impaired. The results suggest that CA1 hippocampal LTP is controlled by the number or subunit composition of AMPA receptors and show a dichotomy between LTP in CA1 and acquisition of spatial memory.

Original languageEnglish (US)
Pages (from-to)1805-1811
Number of pages7
JournalScience
Volume284
Issue number5421
DOIs
StatePublished - Jun 11 1999

ASJC Scopus subject areas

  • General

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