@article{5bab648e27f9441a958cd89128639104,
title = "Implications of Look AHEAD for clinical trials and clinical practice",
abstract = "Look AHEAD (Action for Health in Diabetes) was a randomized clinical trial designed to examine the long-term health effects of weight loss in overweight and obese individuals with type 2 diabetes. The primary result was that the incidence of cardiovascular events over a median follow-up of 9.6 years was not reduced in the Intensive Lifestyle Group relative to the control group. This finding is discussed, with emphasis on its implications for design of trials and clinical treatment of obese persons with type 2 diabetes.",
keywords = "Cardiovascular disease, Dietary intervention, Type 2 diabetes",
author = "{for The Look AHEAD Research Group} and Wing, {Rena R.} and Paula Bolin and Brancati, {Frederick L.} and Bray, {George A.} and Clark, {Jeanne M.} and Mace Coday and Crow, {Richard S.} and Curtis, {Jeffrey M.} and Egan, {Caitlin M.} and Espeland, {Mark A.} and Mary Evans and Foreyt, {John P.} and Siran Ghazarian and Gregg, {Edward W.} and Barbara Harrison and Hazuda, {Helen P.} and Hill, {James O.} and Horton, {Edward S.} and Hubbard, {Van S.} and Jakicic, {John M.} and Jeffery, {Robert W.} and Johnson, {Karen C.} and Kahn, {Steven E.} and Kitabchi, {Abbas E.} and Knowler, {William C.} and Lewis, {Cora E.} and Barbara, {Maschak Carey} and Montez, {Maria G.} and Anne Murillo and Nathan, {David M.} and Jennifer Patricio and Anne Peters and Xavier, {Pi Sunyer} and Henry Pownall and David Reboussin and Regensteiner, {Judith G.} and Rickman, {Amy D.} and Ryan, {Donna H.} and Monika Safford and Wadden, {Thomas A.} and Wagenknecht, {Lynne E.} and West, {Delia S.} and Williamson, {David F.} and Yanovski, {Susan Z.} and L. Brancati and Lee Swartzc and Jeanne Charleston and Lawrence Cheskin and Kerry Stewart and Richard Rubin",
note = "Publisher Copyright: {\textcopyright} 2014 John Wiley & Sons Ltd.",
year = "2014",
month = dec,
day = "1",
doi = "10.1111/dom.12318",
language = "English (US)",
volume = "16",
pages = "1183--1191",
journal = "Diabetes, Obesity and Metabolism",
issn = "1462-8902",
publisher = "Wiley-Blackwell",
number = "12",
}