Implications of hypoxia in breast cancer metastasis to bone

Research output: Contribution to journalReview article

Abstract

Most solid tumors contain regions of hypoxia in which increased cell proliferation promotes increased oxygen consumption and the condition is further exacerbated as cancer cells become localized far from a functional blood vessel, further decreasing the oxygen supply. An important mechanism that promotes cell adaptation to hypoxic conditions is the expression of hypoxia-inducible factors (HIFs). Hypoxia-inducible factors transcriptionally regulate many genes involved in the invasion and metastasis of breast cancer cells. Patients, whose primary tumor biopsies show high HIF expression levels, have a greater risk of metastasis. The current review will highlight the potential role of hypoxia in breast cancer metastasis to the bone by considering the regulation of many steps in the metastatic process that include invasion, migration, margination and extravasation, as well as homing signals and regulation of the bone microenvironment.

Original languageEnglish (US)
Article number1669
JournalInternational Journal of Molecular Sciences
Volume17
Issue number10
DOIs
StatePublished - Oct 1 2016

Fingerprint

hypoxia
metastasis
breast
bones
Tumors
Bone
cancer
Cells
Breast Neoplasms
Neoplasm Metastasis
Oxygen supply
Bone and Bones
Biopsy
Blood vessels
Cell proliferation
Genes
Oxygen
tumors
homing
oxygen consumption

Keywords

  • Bone
  • Breast cancer
  • Hypoxia
  • Hypoxia-inducible factors (HIFs)
  • Invasion
  • Metastasis
  • Migration

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Computer Science Applications
  • Spectroscopy
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

Implications of hypoxia in breast cancer metastasis to bone. / Gilkes, Daniele.

In: International Journal of Molecular Sciences, Vol. 17, No. 10, 1669, 01.10.2016.

Research output: Contribution to journalReview article

@article{7a40958bbaf540c59cf8a1f5243370eb,
title = "Implications of hypoxia in breast cancer metastasis to bone",
abstract = "Most solid tumors contain regions of hypoxia in which increased cell proliferation promotes increased oxygen consumption and the condition is further exacerbated as cancer cells become localized far from a functional blood vessel, further decreasing the oxygen supply. An important mechanism that promotes cell adaptation to hypoxic conditions is the expression of hypoxia-inducible factors (HIFs). Hypoxia-inducible factors transcriptionally regulate many genes involved in the invasion and metastasis of breast cancer cells. Patients, whose primary tumor biopsies show high HIF expression levels, have a greater risk of metastasis. The current review will highlight the potential role of hypoxia in breast cancer metastasis to the bone by considering the regulation of many steps in the metastatic process that include invasion, migration, margination and extravasation, as well as homing signals and regulation of the bone microenvironment.",
keywords = "Bone, Breast cancer, Hypoxia, Hypoxia-inducible factors (HIFs), Invasion, Metastasis, Migration",
author = "Daniele Gilkes",
year = "2016",
month = "10",
day = "1",
doi = "10.3390/ijms17101669",
language = "English (US)",
volume = "17",
journal = "International Journal of Molecular Sciences",
issn = "1661-6596",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "10",

}

TY - JOUR

T1 - Implications of hypoxia in breast cancer metastasis to bone

AU - Gilkes, Daniele

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Most solid tumors contain regions of hypoxia in which increased cell proliferation promotes increased oxygen consumption and the condition is further exacerbated as cancer cells become localized far from a functional blood vessel, further decreasing the oxygen supply. An important mechanism that promotes cell adaptation to hypoxic conditions is the expression of hypoxia-inducible factors (HIFs). Hypoxia-inducible factors transcriptionally regulate many genes involved in the invasion and metastasis of breast cancer cells. Patients, whose primary tumor biopsies show high HIF expression levels, have a greater risk of metastasis. The current review will highlight the potential role of hypoxia in breast cancer metastasis to the bone by considering the regulation of many steps in the metastatic process that include invasion, migration, margination and extravasation, as well as homing signals and regulation of the bone microenvironment.

AB - Most solid tumors contain regions of hypoxia in which increased cell proliferation promotes increased oxygen consumption and the condition is further exacerbated as cancer cells become localized far from a functional blood vessel, further decreasing the oxygen supply. An important mechanism that promotes cell adaptation to hypoxic conditions is the expression of hypoxia-inducible factors (HIFs). Hypoxia-inducible factors transcriptionally regulate many genes involved in the invasion and metastasis of breast cancer cells. Patients, whose primary tumor biopsies show high HIF expression levels, have a greater risk of metastasis. The current review will highlight the potential role of hypoxia in breast cancer metastasis to the bone by considering the regulation of many steps in the metastatic process that include invasion, migration, margination and extravasation, as well as homing signals and regulation of the bone microenvironment.

KW - Bone

KW - Breast cancer

KW - Hypoxia

KW - Hypoxia-inducible factors (HIFs)

KW - Invasion

KW - Metastasis

KW - Migration

UR - http://www.scopus.com/inward/record.url?scp=84991409019&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84991409019&partnerID=8YFLogxK

U2 - 10.3390/ijms17101669

DO - 10.3390/ijms17101669

M3 - Review article

C2 - 27706047

AN - SCOPUS:84991409019

VL - 17

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1661-6596

IS - 10

M1 - 1669

ER -