TY - JOUR
T1 - Implementing the National Academy's vision and strategy for toxicity testing
T2 - Opportunities and challenges under the U.S. toxic substances control act
AU - Locke, Paul A.
AU - Bruce Myers, D.
N1 - Funding Information:
In 2007, the U.S. National Academy of Sciences, National Research Council (NRC), issued the report Toxicity Testing in the 21st Century: A Vision and a Strategy. This report, which was commissioned by the U.S. Environmental Protection Agency (EPA), called for the U.S. EPA to develop a new approach for how this agency evaluates the toxicity of compounds. The report recommended that the agency move from its current testing system, which is based largely on traditional toxicology, to a testing system that is based primarily on human cell lines and in vitro systems. Successful implementation of the report’s vision and strategy will require that scientists, lawyers, and policymakers work together to bridge the gap among disciplines. An important step in building this bridge requires an analysis of the U.S. legal system that frames toxicity testing. If the U.S. laws, regulations, and policies erect barriers that would prevent or impede the U.S. EPA adoption of the NRC vision and strategy, it is important to identify these challenges. At the same time, if existing laws, regulations, and policies are fertile ground for these recommendations, opportunities should be documented. This article discusses and evaluates the challenges and opportunities that arise under key provisions of one major U.S. toxics law, the Toxics Substances Control Act (TSCA).
Funding Information:
In the United States, two important federal laws control the use of toxic chemicals. The Toxic Substances Control Act (TSCA) (TSCA, 2010) controls chemicals in commerce. The Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) (FIFRA, 2010) controls the use of pesticides, insecticides, and other poisons used to combat pests. TSCA and FIFRA are administered by the U.S. Environmental Protection Agency (EPA). Implementation of the NRC vision and strategy depends in part upon whether these laws provide a functional platform for, or create obstacles to, the use of the toxicity testing system called for in the NRC report. As a first step in assessing the suitability of adopting the NAS vision and strategy in current U.S. laws, this article examines and analyzes TSCA’s key provisions, a portion of its legislative history, and its regulatory structure (Environmental Law Institute, 2008).
PY - 2010/2
Y1 - 2010/2
N2 - In 2007, the U.S. National Academy of Sciences, National Research Council (NRC), issued the report Toxicity Testing in the 21st Century: A Vision and a Strategy. This report, which was commissioned by the U.S. Environmental Protection Agency (EPA), called for the U.S. EPA to develop a new approach for how this agency evaluates the toxicity of compounds. The report recommended that the agency move from its current testing system, which is based largely on traditional toxicology, to a testing system that is based primarily on human cell lines and in vitro systems. Successful implementation of the report's vision and strategy will require that scientists, lawyers, and policymakers work together to bridge the gap among disciplines. An important step in building this bridge requires an analysis of the U.S. legal system that frames toxicity testing. If the U.S. laws, regulations, and policies erect barriers that would prevent or impede the U.S. EPA adoption of the NRC vision and strategy, it is important to identify these challenges. At the same time, if existing laws, regulations, and policies are fertile ground for these recommendations, opportunities should be documented. This article discusses and evaluates the challenges and opportunities that arise under key provisions of one major U.S. toxics law, the Toxics Substances Control Act (TSCA).
AB - In 2007, the U.S. National Academy of Sciences, National Research Council (NRC), issued the report Toxicity Testing in the 21st Century: A Vision and a Strategy. This report, which was commissioned by the U.S. Environmental Protection Agency (EPA), called for the U.S. EPA to develop a new approach for how this agency evaluates the toxicity of compounds. The report recommended that the agency move from its current testing system, which is based largely on traditional toxicology, to a testing system that is based primarily on human cell lines and in vitro systems. Successful implementation of the report's vision and strategy will require that scientists, lawyers, and policymakers work together to bridge the gap among disciplines. An important step in building this bridge requires an analysis of the U.S. legal system that frames toxicity testing. If the U.S. laws, regulations, and policies erect barriers that would prevent or impede the U.S. EPA adoption of the NRC vision and strategy, it is important to identify these challenges. At the same time, if existing laws, regulations, and policies are fertile ground for these recommendations, opportunities should be documented. This article discusses and evaluates the challenges and opportunities that arise under key provisions of one major U.S. toxics law, the Toxics Substances Control Act (TSCA).
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U2 - 10.1080/10937404.2010.483952
DO - 10.1080/10937404.2010.483952
M3 - Review article
C2 - 20574909
AN - SCOPUS:77953998797
SN - 1093-7404
VL - 13
SP - 376
EP - 384
JO - Journal of Toxicology and Environmental Health - Part B: Critical Reviews
JF - Journal of Toxicology and Environmental Health - Part B: Critical Reviews
IS - 2-4
ER -