Implementing genome-informed personalized medicine in the U.S. Air Force Medical Service via the Patient-Centered Precision Care Research (PC2-Z) Program

Christopher E. Bradburne, Lucy M. Carruth, Jeffrey S. Lin, Ashok Sivakumar, John H. Benson, Ruth A. Vogel

Research output: Contribution to journalArticle

Abstract

Personal genomic information is poised to revolutionize medicine and provide patients with increasingly individualized medical care. Advances in genomic typing and sequencing technologies are making access to inexpensive, personal genomic information a rapidly evolving reality. However, the effective integration of genomic information into clinical care will pose many logistical, ethical, and legal challenges moving forward. In response to this rapidly evolving health care revolution, the U.S. Air Force (USAF) has established the Patient-Centered Precision Care Research (PC2-Z) Program. The aim of this program is to evaluate the clinical impact of genome-informed care and to begin to lay the foundation for its implementation in the USAF. The PC2-Z program's overarching goal is to gather clinical knowledge and provide recommendations for translating genome-informed medicine into personalized health care for DoD personnel and beneficiaries. APL is serving as the program integrator for this groundbreaking program, bringing together the government, academic, and industry partners to implement program focus areas in research, bioinformatics, education, and policy. A centerpiece of the program is a study enrolling active duty volunteers from the Air Force Medical Service to evaluate the utility of their genomic information and its effect on their personalized care and on their behavior. The data, evidence, and infrastructure developed in the PC2-Z program are also planned to be implemented by the sister services.

Original languageEnglish (US)
Pages (from-to)333-344
Number of pages12
JournalJohns Hopkins APL Technical Digest (Applied Physics Laboratory)
Volume31
Issue number4
StatePublished - Feb 1 2013

ASJC Scopus subject areas

  • Engineering(all)
  • Physics and Astronomy(all)

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