Implementation of systemic hedgehog inhibitors in daily practice as neoadjuvant therapy

Nikki Tang, Desiree Ratner

Research output: Contribution to journalReview article

Abstract

The most common cancer in both men and women is basal cell carcinoma (BCC). Although most primary and recurrent BCCs have high cure rates with standard therapies, advanced BCCs present a greater treatment challenge, especially in cosmetically and functionally sensitive areas. In patients unable to undergo surgery or radiation therapy, hedgehog inhibitors can be used neoadjuvantly to reduce tumor size, decreasing the extent and complexity of any subsequent surgery and providing either a cure or palliation. The goal of this review is to summarize the pharmacology, efficacy, and safety of systemic hedgehog inhibitors, as well as their role in daily practice as neoadjuvant therapy. Relevant English-language literature was identified and evaluated based on results from database searches of PubMed. Terms searched included, but were not limited to, "vismodegib," "Erivedge," "sonidegib," "DE225," "BCC," and "neoadjuvant treatment." Additional literature was identified from the reference lists of previously identified articles. The authors' personal experience in treating advanced BCC using hedgehog inhibitors has been incorporated into the recommendations made herein.

Original languageEnglish (US)
Pages (from-to)537-543
Number of pages7
JournalJNCCN Journal of the National Comprehensive Cancer Network
Volume15
Issue number4
StatePublished - Apr 1 2017

ASJC Scopus subject areas

  • Oncology

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