TY - JOUR
T1 - Implementation and clinical characteristics of a posttraumatic stress disorder brain collection
AU - Mighdoll, Michelle I.
AU - Deep-Soboslay, Amy
AU - Bharadwaj, Rahul A.
AU - Cotoia, John A.
AU - Benedek, David M.
AU - Hyde, Thomas M.
AU - Kleinman, Joel E.
N1 - Funding Information:
We thank the families of the brain donors who make this research possible. We gratefully acknowledge the Office of the Chief Medical Examiner of the State of Maryland, under the direction of Dr. David Fowler, without whom this work would not have been possible. We acknowledge the Office of the Medical Examiner in Kalamazoo, Michigan, and the Western Michigan University Homer Stryker M.D. School of Medicine Neuropathology Department under the direction of Dr. Joyce de Jong, for their highly valued collaboration. We also thank Anna Brandtjen, Julia Grossman, Taylor Pinckney, and Dr. Llewelyn Bigelow for their assistance in clinical characterization and sample acquisition.
Publisher Copyright:
© 2017 Wiley Periodicals, Inc.
PY - 2018/1
Y1 - 2018/1
N2 - A postmortem human brain collection to study posttraumatic stress disorder (PTSD) is critical for uncovering the molecular mechanisms that contribute to this psychiatric disorder. We describe here the PTSD brain collection at the Lieber Institute for Brain Development in Baltimore, Maryland, consisting of postmortem brain donations acquired between 2012 and 2017. Thus far, 87 brains from individuals meeting DSM-5 criteria for PTSD were collected after consent was obtained from legal next-of-kin, and subsequently clinically characterized for molecular studies. PTSD brain donors had high rates of comorbid diagnoses, including depression (62.1%), substance abuse (74.7%), drug-related death (69.0%), and suicide completion (17.2%). PTSD cases were subdivided into two categories: combat-related PTSD (n = 24) and noncombat/domestic PTSD (n = 63). The major differences between the combat-related and domestic PTSD cohorts were sex, drug-related death, and the prevalence of bipolar disorder (BPD) comorbidity. The combat-related group was entirely male, with only one BPD subject (4.2%), and had significantly fewer drug-related deaths (45.8%) in contrast to the domestic group (31.8% male, 36.5% bipolar, and 77.8% drug-related deaths). Medical examiners' offices, particularly in areas with higher military populations, are an excellent source for PTSD brain donations of both combat-related and domestic PTSD.
AB - A postmortem human brain collection to study posttraumatic stress disorder (PTSD) is critical for uncovering the molecular mechanisms that contribute to this psychiatric disorder. We describe here the PTSD brain collection at the Lieber Institute for Brain Development in Baltimore, Maryland, consisting of postmortem brain donations acquired between 2012 and 2017. Thus far, 87 brains from individuals meeting DSM-5 criteria for PTSD were collected after consent was obtained from legal next-of-kin, and subsequently clinically characterized for molecular studies. PTSD brain donors had high rates of comorbid diagnoses, including depression (62.1%), substance abuse (74.7%), drug-related death (69.0%), and suicide completion (17.2%). PTSD cases were subdivided into two categories: combat-related PTSD (n = 24) and noncombat/domestic PTSD (n = 63). The major differences between the combat-related and domestic PTSD cohorts were sex, drug-related death, and the prevalence of bipolar disorder (BPD) comorbidity. The combat-related group was entirely male, with only one BPD subject (4.2%), and had significantly fewer drug-related deaths (45.8%) in contrast to the domestic group (31.8% male, 36.5% bipolar, and 77.8% drug-related deaths). Medical examiners' offices, particularly in areas with higher military populations, are an excellent source for PTSD brain donations of both combat-related and domestic PTSD.
KW - BPD–bipolar disorder
KW - MDD–major depressive disorder
KW - PTSD
KW - combat PTSD
KW - domestic PTSD
KW - postmortem human brain collection
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U2 - 10.1002/jnr.24093
DO - 10.1002/jnr.24093
M3 - Letter
C2 - 28609565
AN - SCOPUS:85020405833
SN - 0360-4012
VL - 96
SP - 16
EP - 20
JO - Journal of neuroscience research
JF - Journal of neuroscience research
IS - 1
ER -