Impedance spectroscopic detection of binding and reactions in acid-labile dielectric polymers for biosensor applications

Jennifer Dailey, Michelangelo Fichera, Ellen Silbergeld, Howard E. Katz

Research output: Contribution to journalArticle

Abstract

We synthesized previously unreported copolymers with cleavable acid-labile side chains for use as electrochemical sensing layers in order to demonstrate a novel architecture for a one-step immunosensor. This one-step system is in contrast to most antigen-capture signal amplification methods that involve complicated secondary labeling techniques, or require the addition of redox probes to achieve a sensing response. A series of novel copolymers composed of various trityl-containing monomers were synthesized and characterized to determine their dielectric properties. The results indicate that the thin films of these polymers are stable in water, but some begin to degrade under acidic conditions or upon antigen binding, causing observable changes in the phase angle.

Original languageEnglish (US)
Pages (from-to)2972-2981
Number of pages10
JournalJournal of Materials Chemistry B
Volume6
Issue number19
DOIs
StatePublished - Jan 1 2018

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Antigens
Biosensors
Polymers
Copolymers
Immunosensors
Acids
Dielectric properties
Labeling
Amplification
Monomers
Thin films
Water
Oxidation-Reduction

ASJC Scopus subject areas

  • Chemistry(all)
  • Biomedical Engineering
  • Materials Science(all)

Cite this

Impedance spectroscopic detection of binding and reactions in acid-labile dielectric polymers for biosensor applications. / Dailey, Jennifer; Fichera, Michelangelo; Silbergeld, Ellen; Katz, Howard E.

In: Journal of Materials Chemistry B, Vol. 6, No. 19, 01.01.2018, p. 2972-2981.

Research output: Contribution to journalArticle

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