@article{b46062feb044442584d5bb38f4361c12,
title = "Impairments in memory and hippocampal function in HIV-positive vs HIV-negative women A preliminary study",
abstract = "Objective: Neurocognitive studies of HIV typically target executive functions dependent on fron-tostriatal circuitry. The integrity of medial temporal systems has received considerably less attention despite high hippocampal viral load. Studies also predominately involve HIV+ men, though HIV+ women may be at increased risk for cognitive dysfunction due to the high prevalence of psychosocial/mental health problems and lower educational attainment. Our aim was to conduct a preliminary investigation of episodic memory and its neural correlates in HIV-infected and at-risk uninfected women. Methods: Participants included 54 HIV+ and 12 HIV- women (mean age = 43 years; 86% African American) recruited from the Chicago site of the Women's Interagency HIV Study. Participants completed standardized tests of verbal and visual episodic memory, working memory, and executive function. A subset of 11 women also underwent functional MRI during a delayed verbal episodic memory task. Results: HIV serostatus predicted significantly lower immediate and delayed verbal episodic memory, working memory, and visual memory. Preliminary neuroimaging findings revealed group differences in bilateral hippocampal function, with HIV+ women showing decreased activation during encoding and increased activation during delayed recognition. These alterations correlated with worse episodic verbal memory. Conclusions: Verbal episodic memory deficits are evident in HIV+ women and may be associated with hippocampal dysfunction at both encoding and retrieval",
author = "Maki, {P. M.} and Cohen, {M. H.} and K. Weber and Little, {D. M.} and D. Fornelli and Rubin, {L. H.} and P. Perschler and F. Gould and E. Martin",
note = "Funding Information: This work was supported by NIH/NIAID grant U01-AI-34993, the Chicago Consortium Women's Interagency HIV Study, to Mardge Cohen, MD (PI). Chicago WIHS is cofunded by the NCI and NIDA. Dr. Maki has received grant support from the National Institute on Allergy and Infectious Disease (NIAID), National Center on Complementary and Alternative Medicine, Soy Health Research Board, and Wyeth Ayerst. Dr. Maki has also received honorarium from the National Institutes of Health (NIH), Soy Research Foundation, Northwestern Memorial Hospital, the North American Menopause Association, Wyeth Pharmaceuticals, Fanizzi Associates, and Genaera Corporation. Dr. Cohen and Kathleen Weber received grant support from the NIAID and the National Institute on Mental Health (NIMH). Dr. Little has received research grants from the National Institute on Aging, NIMH, Congressionally Directed Medical Research Program, Department of Defense, and the Chicago Institute for Neuroscience and Neuroresearch. Dr. Little has also received honoraria from the Centre for Neuroskills and serves on the advisory board of the Sarah Jane Brain Foundation. Leah Rubin received NIH grant support from the NIMH. Dr. Gould received grant support from the University of Miami Developmental Center for AIDS Research (D-CFAR) and National Institute on Child Health and Human Development. Dr. Martin has received grant support from the NIAID, National Institute on Drug Abuse, Veterans Administration Merit Review Board, Glaxo-Wellcome, University of Illinois Campus Research Board, and University of Illinois Center for Research on Women and Gender. Dr Martin has received honorarium from the NIH, University of California-San Diego, San Francisco VAMC, and the Michael Smith Research Foundation.",
year = "2009",
month = may,
day = "12",
doi = "10.1212/WNL.0b013e3181a55f65",
language = "English (US)",
volume = "72",
pages = "1661--1668",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "19",
}