TY - JOUR
T1 - Impairment of thymus‐derived lymphoid cell function in patients with basal cell carcinoma
AU - Dellon, A. Lee
AU - Elfenbein, Gerald J.
AU - Orlando, Joseph C.
PY - 1984/2
Y1 - 1984/2
N2 - The host‐tumor relationships in 34 patients with basal cell carcinoma was investigated by characterizing thymus‐derived (T) and bone marrow‐derived (B) lymphoid subpopulations in the blood by cell surface markers and lymphoid function in vitro by proliferative responses to mitogenic and antigenic stimulation. Results were correlated with tumor stage. In patients with tumor present, the data demonstrate significantly (P < .02) decreased responsiveness of T cells to the lectin mitogens phytohemagglutinin and concanavalin A, and further demonstrate significantly decreased responsiveness of T cells to antigens (P < .001 for Candida antigen, P < .05 for Staphylococcal filtrate and Streptococcal varidase). In patients who were grossly disease free after resection of tumors, there was no significant difference in these responses from normal. These results document, for the first time, impaired T‐cell function in patients with basal cell carcinoma and suggest that the functional impairment is tumor induced.
AB - The host‐tumor relationships in 34 patients with basal cell carcinoma was investigated by characterizing thymus‐derived (T) and bone marrow‐derived (B) lymphoid subpopulations in the blood by cell surface markers and lymphoid function in vitro by proliferative responses to mitogenic and antigenic stimulation. Results were correlated with tumor stage. In patients with tumor present, the data demonstrate significantly (P < .02) decreased responsiveness of T cells to the lectin mitogens phytohemagglutinin and concanavalin A, and further demonstrate significantly decreased responsiveness of T cells to antigens (P < .001 for Candida antigen, P < .05 for Staphylococcal filtrate and Streptococcal varidase). In patients who were grossly disease free after resection of tumors, there was no significant difference in these responses from normal. These results document, for the first time, impaired T‐cell function in patients with basal cell carcinoma and suggest that the functional impairment is tumor induced.
KW - T‐cell function
KW - basal cell carcinoma
KW - host‐tumor relationship
KW - lymphoid function
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U2 - 10.1002/jso.2930250208
DO - 10.1002/jso.2930250208
M3 - Article
C2 - 6607384
AN - SCOPUS:0021328193
SN - 0022-4790
VL - 25
SP - 92
EP - 97
JO - Journal of Surgical Oncology
JF - Journal of Surgical Oncology
IS - 2
ER -