Impairment of neutrophil antifungal activity against hyphae of Aspergillus fumigatus in children infected with human immunodeficiency virus

Emmanuel Roilides, Andrew Holmes, Cassann Blake, Philip A. Pizzo, Thomas J. Walsh

Research output: Contribution to journalArticle

Abstract

Human immunodeficiency virus (HIV)-infected patients may acquire invasive aspergillosis without previously recognized risk factors, such as neutropenia or corticosteroid therapy. Because neutrophils (PMNL) are an important component of host defense in aspergillosis, the antifungal activity of PMNL against hyphae of Aspergillus fumigatus in 31 HIV-infected children was assessed. Hyphal damage was unaffected in 15 HIV-infected children with age-adjusted CD4 cell counts ≥25% of the normal median value; it was decreased in 16 with CD4 cell counts

Original languageEnglish (US)
Pages (from-to)905-911
Number of pages7
JournalJournal of Infectious Diseases
Volume167
Issue number4
StatePublished - Apr 1993
Externally publishedYes

Fingerprint

Aspergillus fumigatus
Hyphae
Neutrophils
Aspergillosis
HIV
CD4 Lymphocyte Count
Neutropenia
Adrenal Cortex Hormones
Reference Values
Therapeutics

ASJC Scopus subject areas

  • Immunology
  • Public Health, Environmental and Occupational Health

Cite this

Impairment of neutrophil antifungal activity against hyphae of Aspergillus fumigatus in children infected with human immunodeficiency virus. / Roilides, Emmanuel; Holmes, Andrew; Blake, Cassann; Pizzo, Philip A.; Walsh, Thomas J.

In: Journal of Infectious Diseases, Vol. 167, No. 4, 04.1993, p. 905-911.

Research output: Contribution to journalArticle

Roilides, Emmanuel ; Holmes, Andrew ; Blake, Cassann ; Pizzo, Philip A. ; Walsh, Thomas J. / Impairment of neutrophil antifungal activity against hyphae of Aspergillus fumigatus in children infected with human immunodeficiency virus. In: Journal of Infectious Diseases. 1993 ; Vol. 167, No. 4. pp. 905-911.
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