Impairment of growth of Leishmania donovani by Trypanosoma brucei during co-culture

C. Coppens, B. H. Ter Kuile, F. R. Opperdoes

Research output: Contribution to journalArticlepeer-review

Abstract

Cells of Leishrnania donovani in co-culture with Trypanosoma brucei, were severely affected in their growth, resulting in swelling and subsequent lysis. Similar effects were also observed when Crithidia luciliae or Phytomonas sp. were co-cultured with T. brucei. Direct contact between the cells under investigation and T. brucei was necessary because T. brucei did not hamper the growth of the other trypanosomatids, when separated by a filter with 0.2 μm pore size. Examination of this phenomenon at the ultrastructural level, in a co-culture of L. donovani and T. brucei, suggests that the plasma membrane permeability is increased in the former, as a result of a close cellular contact between the two cell types.

Original languageEnglish (US)
Pages (from-to)393-398
Number of pages6
JournalParasitology
Volume105
Issue number3
DOIs
StatePublished - Dec 1992
Externally publishedYes

Keywords

  • Crithidia luciliae
  • Leishmania donovani infantum
  • Phytomonas
  • Trypanosoma brucei
  • cytolysis
  • interactions

ASJC Scopus subject areas

  • Parasitology
  • Animal Science and Zoology
  • Infectious Diseases

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