Impairment of antibody response and recovery in malarial rodents by antilymphocyte serum

L. R. Barker, K. G. Powers

Research output: Contribution to journalArticle

Abstract

HETEROLOGOUS antilymphocyte serum (ALS) is a very potent inhibitor of cell-mediated immune responses such as homograft rejection and delayed hypersensitivity1. It has also been shown to suppress the antibody response to inert antigens such as sheep red blood cells and bacterial products in rodents and other laboratory animals1-3. By contrast, in the several infections of rodents in which the antibody response has been followed, including trichinosis in rats4 and several viral infections of mice5,6, ALS impaired recovery, but the antibody response was not altered. It is therefore of interest that we have found a marked delay in the antibody response associated with delayed recovery from a malaria infection in ALS-treated mice.

Original languageEnglish (US)
Pages (from-to)429-430
Number of pages2
JournalNature
Volume229
Issue number5284
DOIs
StatePublished - Dec 1 1971
Externally publishedYes

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Impairment of antibody response and recovery in malarial rodents by antilymphocyte serum'. Together they form a unique fingerprint.

  • Cite this