Impairment in semantic retrieval is associated with symptoms in schizophrenia but not bipolar disorder

Sharna Jamadar, Kasey M. O'Neil, Godfrey D. Pearlson, Mahvesh Ansari, Adrienne Gill, Kanchana Jagannathan, Michal Assaf

Research output: Contribution to journalArticle

Abstract

Background: The Semantic Object Retrieval Task (SORT) requires participants to indicate whether word pairs recall a third object. Schizophrenia individuals (SZ) tend to report associations between nonassociated word pairs; this overretrieval is related to formal thought disorder (FTD). Since semantic memory impairments and psychosis are also found in bipolar disorder (BP), we examined whether SORT impairments and their relationship to symptoms are also present in BP. Methods: Participants (n = 239; healthy control subjects [HC] = 133; BP = 32; SZ = 74) completed SORT while undergoing functional magnetic resonance imaging (fMRI) scanning. Results: Retrieval accuracy negatively correlated with negative symptoms and no-retrieval accuracy negatively correlated with FTD severity in SZ but not BP. Retrieval versus no-retrieval trials activated a distributed fronto-parieto-temporal network; bilateral inferior parietal lobule (IPL) activity was larger in HC versus SZ and HC versus BP, with no difference in SZ versus BP. Right IPL activity positively correlated with positive and general psychosis symptoms in SZ but not BP. Conclusions: SZ reported more associations between unrelated word pairs than HC; this overretrieval increased with FTD severity. Schizophrenia individuals were also more likely to fail to find associations between related word pairs; this underretrieval increased with negative symptom severity. fMRI symptom correlations in IPL in SZ are consistent with arguments that IPL abnormality relates to loosening of associations in SZ. By comparison, BP showed intermediate impairments on SORT, uncorrelated with symptoms, suggesting that the relationship between SORT performance, fMRI activity, and psychotic symptoms is schizophrenia-specific.

Original languageEnglish (US)
Pages (from-to)555-564
Number of pages10
JournalBiological Psychiatry
Volume73
Issue number6
DOIs
StatePublished - Mar 15 2013
Externally publishedYes

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Bipolar Disorder
Semantics
Schizophrenia
Parietal Lobe
Healthy Volunteers
Magnetic Resonance Imaging
Psychotic Disorders
Task Performance and Analysis

Keywords

  • Bipolar disorder
  • fMRI
  • formal thought disorder
  • positive symptoms
  • schizophrenia
  • semantic association retrieval task

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Jamadar, S., O'Neil, K. M., Pearlson, G. D., Ansari, M., Gill, A., Jagannathan, K., & Assaf, M. (2013). Impairment in semantic retrieval is associated with symptoms in schizophrenia but not bipolar disorder. Biological Psychiatry, 73(6), 555-564. https://doi.org/10.1016/j.biopsych.2012.07.027

Impairment in semantic retrieval is associated with symptoms in schizophrenia but not bipolar disorder. / Jamadar, Sharna; O'Neil, Kasey M.; Pearlson, Godfrey D.; Ansari, Mahvesh; Gill, Adrienne; Jagannathan, Kanchana; Assaf, Michal.

In: Biological Psychiatry, Vol. 73, No. 6, 15.03.2013, p. 555-564.

Research output: Contribution to journalArticle

Jamadar, S, O'Neil, KM, Pearlson, GD, Ansari, M, Gill, A, Jagannathan, K & Assaf, M 2013, 'Impairment in semantic retrieval is associated with symptoms in schizophrenia but not bipolar disorder', Biological Psychiatry, vol. 73, no. 6, pp. 555-564. https://doi.org/10.1016/j.biopsych.2012.07.027
Jamadar, Sharna ; O'Neil, Kasey M. ; Pearlson, Godfrey D. ; Ansari, Mahvesh ; Gill, Adrienne ; Jagannathan, Kanchana ; Assaf, Michal. / Impairment in semantic retrieval is associated with symptoms in schizophrenia but not bipolar disorder. In: Biological Psychiatry. 2013 ; Vol. 73, No. 6. pp. 555-564.
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