Impairment in mitochondrial cytochrome oxidase gene expression in Alzheimer disease

Krish Chandrasekaran, Tony Giordano, Daniel R. Brady, James Stoll, Lee J. Martin, Stanley I. Rapoport

Research output: Contribution to journalArticle

Abstract

Brains from 5 patients with Alzheimer's disease (AD) showed a 50%-65% decrease in mRNA levels of the mitochondrial-encoded cytochrome oxidase (COX, a marker of oxidative metabolism) subunits I and III in the middle temporal association neocortex, but not in the primary motor cortex, as compared to 5 control brains. The amount of mitochondrial-encoded 12S rRNA was not altered, nor was the amount of nuclear-encoded lactate dehydrogenase B mRNA (a marker of glycolytic metabolism). These data suggest that the decrease in COX I and III subunits mRNA in affected brain regions may contribute to reduced brain oxidative metabolism in AD.

Original languageEnglish (US)
Pages (from-to)336-340
Number of pages5
JournalMolecular Brain Research
Volume24
Issue number1-4
DOIs
StatePublished - Jul 1994

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Keywords

  • Alzheimer's disease
  • Human brain
  • Northern blot
  • Oxidative metabolism
  • Primary motor cortex
  • Synaptic loss
  • Temporal cortex

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

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