Impairment in mitochondrial cytochrome oxidase gene expression in Alzheimer disease

Krish Chandrasekaran; Tony Giordano; Daniel R. Brady; James Stoll; Lee J. Martin; Stanley I. Rapoport

doi:10.1016/0169-328X(94)90147-3

Impairment in mitochondrial cytochrome oxidase gene expression in Alzheimer disease

Krish Chandrasekaran, Tony Giordano, Daniel R. Brady, James Stoll, Lee J. Martin, Stanley I. Rapoport

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Brains from 5 patients with Alzheimer's disease (AD) showed a 50%-65% decrease in mRNA levels of the mitochondrial-encoded cytochrome oxidase (COX, a marker of oxidative metabolism) subunits I and III in the middle temporal association neocortex, but not in the primary motor cortex, as compared to 5 control brains. The amount of mitochondrial-encoded 12S rRNA was not altered, nor was the amount of nuclear-encoded lactate dehydrogenase B mRNA (a marker of glycolytic metabolism). These data suggest that the decrease in COX I and III subunits mRNA in affected brain regions may contribute to reduced brain oxidative metabolism in AD.

Original language	English (US)
Pages (from-to)	336-340
Number of pages	5
Journal	Molecular Brain Research
Volume	24
Issue number	1-4
DOIs	https://doi.org/10.1016/0169-328X(94)90147-3
State	Published - Jul 1994

Keywords

Alzheimer's disease
Human brain
Northern blot
Oxidative metabolism
Primary motor cortex
Synaptic loss
Temporal cortex

ASJC Scopus subject areas

Molecular Biology
Cellular and Molecular Neuroscience

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title = "Impairment in mitochondrial cytochrome oxidase gene expression in Alzheimer disease",

abstract = "Brains from 5 patients with Alzheimer's disease (AD) showed a 50%-65% decrease in mRNA levels of the mitochondrial-encoded cytochrome oxidase (COX, a marker of oxidative metabolism) subunits I and III in the middle temporal association neocortex, but not in the primary motor cortex, as compared to 5 control brains. The amount of mitochondrial-encoded 12S rRNA was not altered, nor was the amount of nuclear-encoded lactate dehydrogenase B mRNA (a marker of glycolytic metabolism). These data suggest that the decrease in COX I and III subunits mRNA in affected brain regions may contribute to reduced brain oxidative metabolism in AD.",

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AU - Chandrasekaran, Krish

AU - Giordano, Tony

AU - Brady, Daniel R.

AU - Stoll, James

AU - Martin, Lee J.

AU - Rapoport, Stanley I.

PY - 1994/7

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AB - Brains from 5 patients with Alzheimer's disease (AD) showed a 50%-65% decrease in mRNA levels of the mitochondrial-encoded cytochrome oxidase (COX, a marker of oxidative metabolism) subunits I and III in the middle temporal association neocortex, but not in the primary motor cortex, as compared to 5 control brains. The amount of mitochondrial-encoded 12S rRNA was not altered, nor was the amount of nuclear-encoded lactate dehydrogenase B mRNA (a marker of glycolytic metabolism). These data suggest that the decrease in COX I and III subunits mRNA in affected brain regions may contribute to reduced brain oxidative metabolism in AD.

KW - Alzheimer's disease

KW - Human brain

KW - Northern blot

KW - Oxidative metabolism

KW - Primary motor cortex

KW - Synaptic loss

KW - Temporal cortex

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