Impairment in mitochondrial cytochrome oxidase gene expression in Alzheimer disease

Krish Chandrasekaran; Tony Giordano; Daniel R. Brady; James Stoll; Lee J. Martin; Stanley I. Rapoport

doi:10.1016/0169-328X(94)90147-3

Impairment in mitochondrial cytochrome oxidase gene expression in Alzheimer disease

Krish Chandrasekaran, Tony Giordano, Daniel R. Brady, James Stoll, Lee J. Martin, Stanley I. Rapoport

School of Medicine

Research output: Contribution to journal › Article

Abstract

Brains from 5 patients with Alzheimer's disease (AD) showed a 50%-65% decrease in mRNA levels of the mitochondrial-encoded cytochrome oxidase (COX, a marker of oxidative metabolism) subunits I and III in the middle temporal association neocortex, but not in the primary motor cortex, as compared to 5 control brains. The amount of mitochondrial-encoded 12S rRNA was not altered, nor was the amount of nuclear-encoded lactate dehydrogenase B mRNA (a marker of glycolytic metabolism). These data suggest that the decrease in COX I and III subunits mRNA in affected brain regions may contribute to reduced brain oxidative metabolism in AD.

Original language	English (US)
Pages (from-to)	336-340
Number of pages	5
Journal	Molecular Brain Research
Volume	24
Issue number	1-4
DOIs	https://doi.org/10.1016/0169-328X(94)90147-3
State	Published - Jul 1994

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Keywords

Alzheimer's disease
Human brain
Northern blot
Oxidative metabolism
Primary motor cortex
Synaptic loss
Temporal cortex

ASJC Scopus subject areas

Molecular Biology
Cellular and Molecular Neuroscience

Cite this

Chandrasekaran, K., Giordano, T., Brady, D. R., Stoll, J., Martin, L. J., & Rapoport, S. I. (1994). Impairment in mitochondrial cytochrome oxidase gene expression in Alzheimer disease. Molecular Brain Research, 24(1-4), 336-340. https://doi.org/10.1016/0169-328X(94)90147-3

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10.1016/0169-328X(94)90147-3