Abstract
Brains from 5 patients with Alzheimer's disease (AD) showed a 50%-65% decrease in mRNA levels of the mitochondrial-encoded cytochrome oxidase (COX, a marker of oxidative metabolism) subunits I and III in the middle temporal association neocortex, but not in the primary motor cortex, as compared to 5 control brains. The amount of mitochondrial-encoded 12S rRNA was not altered, nor was the amount of nuclear-encoded lactate dehydrogenase B mRNA (a marker of glycolytic metabolism). These data suggest that the decrease in COX I and III subunits mRNA in affected brain regions may contribute to reduced brain oxidative metabolism in AD.
Original language | English (US) |
---|---|
Pages (from-to) | 336-340 |
Number of pages | 5 |
Journal | Molecular Brain Research |
Volume | 24 |
Issue number | 1-4 |
DOIs | |
State | Published - Jul 1994 |
Keywords
- Alzheimer's disease
- Human brain
- Northern blot
- Oxidative metabolism
- Primary motor cortex
- Synaptic loss
- Temporal cortex
ASJC Scopus subject areas
- Molecular Biology
- Cellular and Molecular Neuroscience