Abstract
Brains from 5 patients with Alzheimer's disease (AD) showed a 50%-65% decrease in mRNA levels of the mitochondrial-encoded cytochrome oxidase (COX, a marker of oxidative metabolism) subunits I and III in the middle temporal association neocortex, but not in the primary motor cortex, as compared to 5 control brains. The amount of mitochondrial-encoded 12S rRNA was not altered, nor was the amount of nuclear-encoded lactate dehydrogenase B mRNA (a marker of glycolytic metabolism). These data suggest that the decrease in COX I and III subunits mRNA in affected brain regions may contribute to reduced brain oxidative metabolism in AD.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 336-340 |
| Number of pages | 5 |
| Journal | Molecular Brain Research |
| Volume | 24 |
| Issue number | 1-4 |
| DOIs | |
| State | Published - 1994 |
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Keywords
- Alzheimer's disease
- Human brain
- Northern blot
- Oxidative metabolism
- Primary motor cortex
- Synaptic loss
- Temporal cortex
ASJC Scopus subject areas
- Molecular Biology
- Cellular and Molecular Neuroscience
Cite this
Impairment in mitochondrial cytochrome oxidase gene expression in Alzheimer disease. / Chandrasekaran, Krish; Giordano, Tony; Brady, Daniel R.; Stoll, James; Martin, Lee J; Rapoport, Stanley I.
In: Molecular Brain Research, Vol. 24, No. 1-4, 1994, p. 336-340.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Impairment in mitochondrial cytochrome oxidase gene expression in Alzheimer disease
AU - Chandrasekaran, Krish
AU - Giordano, Tony
AU - Brady, Daniel R.
AU - Stoll, James
AU - Martin, Lee J
AU - Rapoport, Stanley I.
PY - 1994
Y1 - 1994
N2 - Brains from 5 patients with Alzheimer's disease (AD) showed a 50%-65% decrease in mRNA levels of the mitochondrial-encoded cytochrome oxidase (COX, a marker of oxidative metabolism) subunits I and III in the middle temporal association neocortex, but not in the primary motor cortex, as compared to 5 control brains. The amount of mitochondrial-encoded 12S rRNA was not altered, nor was the amount of nuclear-encoded lactate dehydrogenase B mRNA (a marker of glycolytic metabolism). These data suggest that the decrease in COX I and III subunits mRNA in affected brain regions may contribute to reduced brain oxidative metabolism in AD.
AB - Brains from 5 patients with Alzheimer's disease (AD) showed a 50%-65% decrease in mRNA levels of the mitochondrial-encoded cytochrome oxidase (COX, a marker of oxidative metabolism) subunits I and III in the middle temporal association neocortex, but not in the primary motor cortex, as compared to 5 control brains. The amount of mitochondrial-encoded 12S rRNA was not altered, nor was the amount of nuclear-encoded lactate dehydrogenase B mRNA (a marker of glycolytic metabolism). These data suggest that the decrease in COX I and III subunits mRNA in affected brain regions may contribute to reduced brain oxidative metabolism in AD.
KW - Alzheimer's disease
KW - Human brain
KW - Northern blot
KW - Oxidative metabolism
KW - Primary motor cortex
KW - Synaptic loss
KW - Temporal cortex
UR - http://www.scopus.com/inward/record.url?scp=0028199881&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028199881&partnerID=8YFLogxK
U2 - 10.1016/0169-328X(94)90147-3
DO - 10.1016/0169-328X(94)90147-3
M3 - Article
C2 - 7968373
AN - SCOPUS:0028199881
VL - 24
SP - 336
EP - 340
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 1-4
ER -