Impaired toll-like receptor 8 signaling in multiple sclerosis

Tory Johnson, Richa Tyagi, Karan Patel, Nicoline Schiess, Peter Calabresi, Avindra Nath

Research output: Contribution to journalArticle

Abstract

Background: The etiology and immunopathology of multiple sclerosis (MS) is not well understood. It is recognized that although autoreactive T cells are the main early mediators of disease, other cell types, including cells of the innate immune system contribute to MS pathogenesis. The objective of this study was to determine if Toll-like receptor (TLR) signaling is functionally altered in patients with MS.Findings: Peripheral blood mononuclear cells from healthy donors and patients with relapsing remitting MS were stimulated with specific agonists of TLRs 3, 7, 8 and 9. Using quantitative polymerase chain reaction transcript levels of tumor necrosis factor-α, interferon-α and interleukin (IL)-12β were quantified from patients with MS and healthy donors. TLR8-induced production of IL12B transcripts and protein was functionally impaired in patients with MS as compared to healthy controls (P

Original languageEnglish (US)
Article number74
JournalJournal of Neuroinflammation
Volume10
DOIs
StatePublished - Jun 21 2013

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Toll-Like Receptor 8
Multiple Sclerosis
Tissue Donors
Relapsing-Remitting Multiple Sclerosis
Toll-Like Receptors
Interleukin-12
Interferons
Immune System
Blood Cells
Tumor Necrosis Factor-alpha
T-Lymphocytes
Polymerase Chain Reaction

Keywords

  • Gene expression
  • Interleukin 12
  • Multiple sclerosis
  • TLR8
  • Toll-like receptor

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Neurology
  • Immunology
  • Neuroscience(all)

Cite this

Impaired toll-like receptor 8 signaling in multiple sclerosis. / Johnson, Tory; Tyagi, Richa; Patel, Karan; Schiess, Nicoline; Calabresi, Peter; Nath, Avindra.

In: Journal of Neuroinflammation, Vol. 10, 74, 21.06.2013.

Research output: Contribution to journalArticle

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