Impaired response inhibition in ill Gulf War veterans

Gail D. Tillman, Timothy A. Green, Thomas C. Ferree, Clifford S. Calley, Mandy J. Maguire, Richard Briggs, John Hart, Robert W. Haley, Michael A Kraut

Research output: Contribution to journalArticle

Abstract

Poor performance on tasks requiring response inhibition has been observed among chronically ill veterans of the 1991 Persian Gulf War. Semantic difficulties have also been reported. We collected event-related potential (ERP) and behavioral data from 25 Gulf War veterans who complained of cognitive difficulties and from 23 matched controls, who were deployed but not symptomatic, while they performed a GO-NOGO task that required both a semantic decision and inhibitory processing. A significantly greater false-alarm rate among the ill veterans was accompanied in the ERP data by significantly reduced amplitude in the NOGO P3, consistent with previous ERP studies of other patient groups that have shown poor inhibitory response performance. This supports the contention that the ill veterans' deficit lies more in inhibiting than in detecting task-related differences in the stimuli.

Original languageEnglish (US)
Pages (from-to)1-5
Number of pages5
JournalJournal of the Neurological Sciences
Volume297
Issue number1-2
DOIs
StatePublished - Oct 15 2010

Fingerprint

Gulf War
Veterans
Evoked Potentials
Semantics
Task Performance and Analysis
Chronic Disease
Inhibition (Psychology)

Keywords

  • Basal ganglia
  • ERP
  • Frontal lobe
  • GO-NOGO
  • Gulf War Illness
  • N2-P3
  • Semantic

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Tillman, G. D., Green, T. A., Ferree, T. C., Calley, C. S., Maguire, M. J., Briggs, R., ... Kraut, M. A. (2010). Impaired response inhibition in ill Gulf War veterans. Journal of the Neurological Sciences, 297(1-2), 1-5. https://doi.org/10.1016/j.jns.2010.07.021

Impaired response inhibition in ill Gulf War veterans. / Tillman, Gail D.; Green, Timothy A.; Ferree, Thomas C.; Calley, Clifford S.; Maguire, Mandy J.; Briggs, Richard; Hart, John; Haley, Robert W.; Kraut, Michael A.

In: Journal of the Neurological Sciences, Vol. 297, No. 1-2, 15.10.2010, p. 1-5.

Research output: Contribution to journalArticle

Tillman, GD, Green, TA, Ferree, TC, Calley, CS, Maguire, MJ, Briggs, R, Hart, J, Haley, RW & Kraut, MA 2010, 'Impaired response inhibition in ill Gulf War veterans', Journal of the Neurological Sciences, vol. 297, no. 1-2, pp. 1-5. https://doi.org/10.1016/j.jns.2010.07.021
Tillman GD, Green TA, Ferree TC, Calley CS, Maguire MJ, Briggs R et al. Impaired response inhibition in ill Gulf War veterans. Journal of the Neurological Sciences. 2010 Oct 15;297(1-2):1-5. https://doi.org/10.1016/j.jns.2010.07.021
Tillman, Gail D. ; Green, Timothy A. ; Ferree, Thomas C. ; Calley, Clifford S. ; Maguire, Mandy J. ; Briggs, Richard ; Hart, John ; Haley, Robert W. ; Kraut, Michael A. / Impaired response inhibition in ill Gulf War veterans. In: Journal of the Neurological Sciences. 2010 ; Vol. 297, No. 1-2. pp. 1-5.
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