Impaired Representation of Time in Schizophrenia Is Linked to Positive Symptoms and Cognitive Demand

Jutta Peterburs, Alexander M. Nitsch, Wolfgang H R Miltner, Thomas Straube

Research output: Contribution to journalArticle

Abstract

Time processing critically relies on the mesencephalic dopamine system and striato-prefrontal projections and has thus been suggested to play a key role in schizophrenia. Previous studies have provided evidence for an acceleration of the internal clock in schizophrenia that may be linked to dopaminergic pathology. The present study aimed to assess the relationship between altered time processing in schizophrenia and symptom manifestation in 22 patients and 22 controls. Subjects were required to estimate the time needed for a visual stimulus to complete a horizontal movement towards a target position on trials of varying cognitive demand. It was hypothesized that patients - compared to controls - would be less accurate at estimating the movement time, and that this effect would be modulated by symptom manifestation and task difficulty. In line with the notion of an accelerated internal clock due to dopaminergic dysregulation, particularly patients with severe positive symptoms were expected to underestimate movement time. However, if altered time perception in schizophrenia was better explained in terms of cognitive deficits, patients with severe negative symptoms should be specifically impaired, while generally, task performance should correlate with measures of processing speed and cognitive flexibility. Patients underestimated movement time on more demanding trials, although there was no link to disease-related cognitive dysfunction. Task performance was modulated by symptom manifestation. Impaired estimation of movement time was significantly correlated with PANSS positive symptom scores, with higher positive symptom scores associated with stronger underestimation of movement time. The present data thus support the notion of a deficit in anticipatory and predictive mechanisms in schizophrenia that is modulated both by symptom manifestation and by cognitive demand.

Original languageEnglish (US)
Article numbere67615
JournalPLoS One
Volume8
Issue number6
DOIs
StatePublished - Jun 27 2013
Externally publishedYes

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Neurobehavioral Manifestations
signs and symptoms (animals and humans)
Schizophrenia
Clocks
Processing
Pathology
Dopamine
Task Performance and Analysis
Time Perception
schizophrenia
dopamine

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Impaired Representation of Time in Schizophrenia Is Linked to Positive Symptoms and Cognitive Demand. / Peterburs, Jutta; Nitsch, Alexander M.; Miltner, Wolfgang H R; Straube, Thomas.

In: PLoS One, Vol. 8, No. 6, e67615, 27.06.2013.

Research output: Contribution to journalArticle

Peterburs, Jutta ; Nitsch, Alexander M. ; Miltner, Wolfgang H R ; Straube, Thomas. / Impaired Representation of Time in Schizophrenia Is Linked to Positive Symptoms and Cognitive Demand. In: PLoS One. 2013 ; Vol. 8, No. 6.
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