TY - JOUR
T1 - Impaired renal function is associated with worse self-reported outcomes after kidney transplantation
AU - Neri, Luca
AU - Dukes, Jonathan
AU - Brennan, Daniel C.
AU - Salvalaggio, Paulo R.
AU - Seelam, Susmitha
AU - Desiraju, Srividya
AU - Schnitzler, Mark
N1 - Funding Information:
Acknowledgments The present paper has been partially funded by BMS pharmaceuticals. The abstract of this work has been presented at the American Transplant Congress held in Boston, (May–June 2009).
PY - 2011/12
Y1 - 2011/12
N2 - We sought to determine the association between health-related quality of life (HRQOL) and graft function in renal transplant recipients. We enrolled 577 kidney transplant recipients aged 18-74 years (response rate 87%). Recipients with multiple or multi-organ transplantation, creatine kinase >200 U/L, acute renal failure or cellular rejection (n = 64), and without creatinine assessments in 3 months pre-enrollment (n = 127) were excluded. The questionnaire included Euro QOL 5 Dimensions (EQ-5D), Health Utility Index III (HUI-III), Kidney Disease Quality of Life-36 (KDQOL36) which include a generic section (RAND SF-12). Data on medical conditions, therapy regimens, and biochemistry results were extracted from clinical charts. We used general linear models adjusted for demographic, socioeconomic, and clinical characteristics to assess the association between HRQOL and severity of chronic kidney disease (CKD). Patients with more advanced CKD were more likely to be African-American, covered by public insurance, more likely to have shorter time after transplantation, higher phosphorus and lower hemoglobin, serum albumin, and calcium levels. All HRQOL scales were inversely associated with CKD severity. All associations were robust to adjustment for possible confounders. Several health-related quality of life dimensions may be affected by poor renal function after transplantation.
AB - We sought to determine the association between health-related quality of life (HRQOL) and graft function in renal transplant recipients. We enrolled 577 kidney transplant recipients aged 18-74 years (response rate 87%). Recipients with multiple or multi-organ transplantation, creatine kinase >200 U/L, acute renal failure or cellular rejection (n = 64), and without creatinine assessments in 3 months pre-enrollment (n = 127) were excluded. The questionnaire included Euro QOL 5 Dimensions (EQ-5D), Health Utility Index III (HUI-III), Kidney Disease Quality of Life-36 (KDQOL36) which include a generic section (RAND SF-12). Data on medical conditions, therapy regimens, and biochemistry results were extracted from clinical charts. We used general linear models adjusted for demographic, socioeconomic, and clinical characteristics to assess the association between HRQOL and severity of chronic kidney disease (CKD). Patients with more advanced CKD were more likely to be African-American, covered by public insurance, more likely to have shorter time after transplantation, higher phosphorus and lower hemoglobin, serum albumin, and calcium levels. All HRQOL scales were inversely associated with CKD severity. All associations were robust to adjustment for possible confounders. Several health-related quality of life dimensions may be affected by poor renal function after transplantation.
KW - End stage renal disease
KW - Health-related quality of life
KW - Quality-adjusted life years
KW - Renal function
KW - Transplantation outcomes
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U2 - 10.1007/s11136-011-9905-8
DO - 10.1007/s11136-011-9905-8
M3 - Article
C2 - 21479956
AN - SCOPUS:84355166790
SN - 0962-9343
VL - 20
SP - 1689
EP - 1698
JO - Quality of Life Research
JF - Quality of Life Research
IS - 10
ER -