Impaired renal function in progressive multiple sclerosis

P. A. Calabresi; H. Austin; M. K. Racke; A. Goodman; P. Choyke; H. Maloni; H. F. McFarland

doi:10.1212/01.WNL.0000036618.68674.7A

Impaired renal function in progressive multiple sclerosis

P. A. Calabresi, H. Austin, M. K. Racke, A. Goodman, P. Choyke, H. Maloni, H. F. McFarland

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

The authors analyzed renal function in 25 patients with progressive MS. The mean glomerular filtration rate (GFR) was 92 mL/min/1.73 m², compared to the predicted GFR of 110 (p < 0.001). Nine of the 25 (36%) patients had abnormally low GFR (<90). The mean serum creatinine for patients with MS was lower than predicted normal values and poorly estimated GFR using standard equations. These data document impaired renal function in patients with progressive MS and have implications for treatment of these patients with potentially nephrotoxic drugs.

Original language	English (US)
Pages (from-to)	1799-1801
Number of pages	3
Journal	Neurology
Volume	59
Issue number	11
DOIs	https://doi.org/10.1212/01.WNL.0000036618.68674.7A
State	Published - Dec 10 2002
Externally published	Yes

ASJC Scopus subject areas

Clinical Neurology

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AU - Calabresi, P. A.

AU - Austin, H.

AU - Racke, M. K.

AU - Goodman, A.

AU - Choyke, P.

AU - Maloni, H.

AU - McFarland, H. F.

PY - 2002/12/10

Y1 - 2002/12/10

N2 - The authors analyzed renal function in 25 patients with progressive MS. The mean glomerular filtration rate (GFR) was 92 mL/min/1.73 m2, compared to the predicted GFR of 110 (p < 0.001). Nine of the 25 (36%) patients had abnormally low GFR (<90). The mean serum creatinine for patients with MS was lower than predicted normal values and poorly estimated GFR using standard equations. These data document impaired renal function in patients with progressive MS and have implications for treatment of these patients with potentially nephrotoxic drugs.

AB - The authors analyzed renal function in 25 patients with progressive MS. The mean glomerular filtration rate (GFR) was 92 mL/min/1.73 m2, compared to the predicted GFR of 110 (p < 0.001). Nine of the 25 (36%) patients had abnormally low GFR (<90). The mean serum creatinine for patients with MS was lower than predicted normal values and poorly estimated GFR using standard equations. These data document impaired renal function in patients with progressive MS and have implications for treatment of these patients with potentially nephrotoxic drugs.

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Impaired renal function in progressive multiple sclerosis

Abstract

ASJC Scopus subject areas

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