Impaired P50 sensory gating in Machado-Joseph disease

Eduardo S. Ghisolfi, Gustavo H B Maegawa, Jefferson Becker, Ana Paula Zanardo, Ivo M. Strimitzer, Alexandre S. Prokopiuk, Maria Luiza Pereira, Thiago Carvalho, Laura B. Jardim, Diogo R. Lara

Research output: Contribution to journalArticle

Abstract

Objective: Machado-Joseph disease (MJD), an autosomal dominant spinocerebellar degeneration caused by an expanded CAG repeat on chromosome 14q32.1, is a disorder with wide range of neurological findings and brain regions involved. Studies evaluating neurophysiological parameters related to sensory gating in MJD are lacking. Methods: This study intends to investigate P50 suppression, an auditory mid-latency evoked potential in a test-conditioning paradigm, considered as an index of sensory gating function. Twelve patients with MJD, 24 normal subjects and 12 schizophrenic patients were evaluated. Results: MJD subjects had higher P50 ratios as compared to normal subjects (76.2 vs. 42.1%, P=0.001), but similar to the group of schizophrenic patients. The difference from controls was due to greater test amplitudes (3.4 vs. 2.0 μV, P=0.002), rather than to conditioning amplitudes. Latencies were higher for the MJD subjects than for controls (60.4 vs. 56.1 ms, P=0.016). Conclusions: MJD may present sensory gating dysfunction. However, the pattern of this dysfunction seems to slightly differ from that classically found in schizophrenia, were both test and conditioning amplitudes seem to be implicated. Significance: These results point out the P50 paradigm as a potential tool for further neurophysiological surveying in MJD.

Original languageEnglish (US)
Pages (from-to)2231-2235
Number of pages5
JournalClinical Neurophysiology
Volume115
Issue number10
DOIs
Publication statusPublished - Oct 2004
Externally publishedYes

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Keywords

  • Event related potentials
  • Machado-Joseph Disease
  • P50
  • Polyglutamine diseases
  • Sensory gating
  • Spinocerebellar ataxias

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Sensory Systems
  • Physiology (medical)

Cite this

Ghisolfi, E. S., Maegawa, G. H. B., Becker, J., Paula Zanardo, A., Strimitzer, I. M., Prokopiuk, A. S., ... Lara, D. R. (2004). Impaired P50 sensory gating in Machado-Joseph disease. Clinical Neurophysiology, 115(10), 2231-2235. https://doi.org/10.1016/j.clinph.2004.04.025