Impaired olfaction and risk of delirium or cognitive decline after cardiac surgery

Charles H. Brown, Candice Morrissey, Masahiro Ono, Gayane Yenokyan, Ola A. Selnes, Jeremy Walston, Laura Max, Andrew LaFlam, Karin Neufeld, Rebecca F. Gottesman, Charles W. Hogue

Research output: Contribution to journalArticle


OBJECTIVES: To determine the prevalence of impaired olfaction in individuals presenting for cardiac surgery and the independent association between impaired olfaction and postoperative delirium and cognitive decline. DESIGN: Nested prospective cohort study. SETTING: Academic hospital. PARTICIPANTS: Individuals undergoing coronary artery bypass, valve surgery, or both (n = 165). MEASUREMENTS: Olfaction was measured using the Brief Smell Identification Test, with impaired olfaction defined as an olfactory score below the fifth percentile of normative data. Delirium was assessed using a validated chart review method. Cognitive performance was assessed using a neuropsychological testing battery at baseline and 4 to 6 weeks after surgery. RESULTS: Impaired olfaction was identified in 54 of 165 participants (33%) before surgery. Impaired olfaction was associated with greater adjusted risk of postoperative delirium (relative risk = 1.90, 95% confidence interval = 1.17-3.09, P = .009). There was no association between impaired olfaction and change in composite cognitive score in the overall study population. CONCLUSION: Impaired olfaction is prevalent in individuals undergoing cardiac surgery and is associated with greater adjusted risk of postoperative delirium but not cognitive decline. Impaired olfaction may identify unrecognized vulnerability to postoperative delirium in individuals undergoing cardiac surgery.

Original languageEnglish (US)
Pages (from-to)16-23
Number of pages8
JournalJournal of the American Geriatrics Society
Issue number1
StatePublished - Jan 1 2015



  • Cognition disorders
  • Delirium
  • Olfaction disorders

ASJC Scopus subject areas

  • Geriatrics and Gerontology

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