Impaired insulin sensitivity is associated with worsening cognition in HIV-infected patients

Saja S. Khuder, Suming Chen, Scott Letendre, Thomas Marcotte, Igor Grant, Donald Franklin, Leah Rubin, Joseph Bernard Margolick, Lisa Paula Jacobson, Ned Sacktor, Gypsyamber D'Souza, Valentina Stosor, Jordan E. Lake, Giovanna Rapocciolo, Justin Charles McArthur, Alex M. Dickens, Norman Haughey

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: To determine the association of insulin sensitivity and metabolic status with declining cognition in HIV-infected individuals. METHODS: We conducted targeted clinical and metabolic measures in longitudinal plasma samples obtained from HIV-infected patients enrolled in the Central Nervous System HIV Anti-Retroviral Therapy Effects Research Study (CHARTER). Findings were validated with plasma samples from the Multicenter AIDS Cohort Study (MACS). Patients were grouped according to longitudinally and serially assessed cognitive performance as having stably normal or declining cognition. RESULTS: Patients with declining cognition exhibited baseline hyperinsulinemia and elevated plasma c-peptide levels with normal c-peptide/insulin ratios, suggesting that insulin production was increased, but insulin clearance was normal. The association of hyperinsulinemia with worsening cognition was further supported by low high-density lipoprotein (HDL), high low-density lipoprotein/HDL ratio, and elevated cholesterol/HDL ratio compared to patients with stably normal cognition. CONCLUSIONS: These findings suggest that hyperinsulinemia and impaired insulin sensitivity are associated with cognitive decline in antiretroviral therapy-treated HIV-infected patients.

Original languageEnglish (US)
Pages (from-to)e1344-e1353
JournalNeurology
Volume92
Issue number12
DOIs
StatePublished - Mar 19 2019

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Cognition
Insulin Resistance
HIV
Hyperinsulinism
HDL Lipoproteins
Insulin
LDL Lipoproteins
Peptides
Hypercholesterolemia
HDL Cholesterol
Acquired Immunodeficiency Syndrome
Cohort Studies
Central Nervous System
Therapeutics
Research

ASJC Scopus subject areas

  • Clinical Neurology

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Khuder, S. S., Chen, S., Letendre, S., Marcotte, T., Grant, I., Franklin, D., ... Haughey, N. (2019). Impaired insulin sensitivity is associated with worsening cognition in HIV-infected patients. Neurology, 92(12), e1344-e1353. https://doi.org/10.1212/WNL.0000000000007125

Impaired insulin sensitivity is associated with worsening cognition in HIV-infected patients. / Khuder, Saja S.; Chen, Suming; Letendre, Scott; Marcotte, Thomas; Grant, Igor; Franklin, Donald; Rubin, Leah; Margolick, Joseph Bernard; Jacobson, Lisa Paula; Sacktor, Ned; D'Souza, Gypsyamber; Stosor, Valentina; Lake, Jordan E.; Rapocciolo, Giovanna; McArthur, Justin Charles; Dickens, Alex M.; Haughey, Norman.

In: Neurology, Vol. 92, No. 12, 19.03.2019, p. e1344-e1353.

Research output: Contribution to journalArticle

Khuder, SS, Chen, S, Letendre, S, Marcotte, T, Grant, I, Franklin, D, Rubin, L, Margolick, JB, Jacobson, LP, Sacktor, N, D'Souza, G, Stosor, V, Lake, JE, Rapocciolo, G, McArthur, JC, Dickens, AM & Haughey, N 2019, 'Impaired insulin sensitivity is associated with worsening cognition in HIV-infected patients', Neurology, vol. 92, no. 12, pp. e1344-e1353. https://doi.org/10.1212/WNL.0000000000007125
Khuder SS, Chen S, Letendre S, Marcotte T, Grant I, Franklin D et al. Impaired insulin sensitivity is associated with worsening cognition in HIV-infected patients. Neurology. 2019 Mar 19;92(12):e1344-e1353. https://doi.org/10.1212/WNL.0000000000007125
Khuder, Saja S. ; Chen, Suming ; Letendre, Scott ; Marcotte, Thomas ; Grant, Igor ; Franklin, Donald ; Rubin, Leah ; Margolick, Joseph Bernard ; Jacobson, Lisa Paula ; Sacktor, Ned ; D'Souza, Gypsyamber ; Stosor, Valentina ; Lake, Jordan E. ; Rapocciolo, Giovanna ; McArthur, Justin Charles ; Dickens, Alex M. ; Haughey, Norman. / Impaired insulin sensitivity is associated with worsening cognition in HIV-infected patients. In: Neurology. 2019 ; Vol. 92, No. 12. pp. e1344-e1353.
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AU - Grant, Igor

AU - Franklin, Donald

AU - Rubin, Leah

AU - Margolick, Joseph Bernard

AU - Jacobson, Lisa Paula

AU - Sacktor, Ned

AU - D'Souza, Gypsyamber

AU - Stosor, Valentina

AU - Lake, Jordan E.

AU - Rapocciolo, Giovanna

AU - McArthur, Justin Charles

AU - Dickens, Alex M.

AU - Haughey, Norman

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