T-lymphocyte subpopulations (Tg or 'suppressor cells' and Tm or 'helper cells') in the peripheral blood of 16 patients with malignant intracranial gliomas were analyzed. The number of TM-lymphocytes was very close to normal in both pre- and postoperative samples, whereas Tg-lymphocytes were significantly increased preoperatively (18.55 ± 1.11 vs. 12.72 ± 1.19, p < 0.001) and were still slightly higher than normal after operation and radiation treatment. These preliminary findings suggest a possible role of T-suppressor lymphocytes in the impairment of cell-mediated immunocompetence that has been observed repeatedly in patients with malignant gliomas.
ASJC Scopus subject areas
- Clinical Neurology