Impaired immunocompetence in patients with malignant gliomas: The possible role of Tg-lymphocyte subpopulations

M. A. Gerosa; A. Olivi; M. L. Rosenblum; G. P. Semenzato; A. Pezzutto

doi:10.1227/00006123-198205000-00004

Impaired immunocompetence in patients with malignant gliomas: The possible role of Tg-lymphocyte subpopulations

M. A. Gerosa, A. Olivi, M. L. Rosenblum, G. P. Semenzato, A. Pezzutto

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Abstract

T-lymphocyte subpopulations (Tg or 'suppressor cells' and Tm or 'helper cells') in the peripheral blood of 16 patients with malignant intracranial gliomas were analyzed. The number of TM-lymphocytes was very close to normal in both pre- and postoperative samples, whereas Tg-lymphocytes were significantly increased preoperatively (18.55 ± 1.11 vs. 12.72 ± 1.19, p < 0.001) and were still slightly higher than normal after operation and radiation treatment. These preliminary findings suggest a possible role of T-suppressor lymphocytes in the impairment of cell-mediated immunocompetence that has been observed repeatedly in patients with malignant gliomas.

Original language	English (US)
Pages (from-to)	571-573
Number of pages	3
Journal	Unknown Journal
Volume	10
Issue number	5
DOIs	https://doi.org/10.1227/00006123-198205000-00004
State	Published - 1982
Externally published	Yes

ASJC Scopus subject areas

Surgery
Clinical Neurology

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title = "Impaired immunocompetence in patients with malignant gliomas: The possible role of Tg-lymphocyte subpopulations",

abstract = "T-lymphocyte subpopulations (Tg or 'suppressor cells' and Tm or 'helper cells') in the peripheral blood of 16 patients with malignant intracranial gliomas were analyzed. The number of TM-lymphocytes was very close to normal in both pre- and postoperative samples, whereas Tg-lymphocytes were significantly increased preoperatively (18.55 ± 1.11 vs. 12.72 ± 1.19, p < 0.001) and were still slightly higher than normal after operation and radiation treatment. These preliminary findings suggest a possible role of T-suppressor lymphocytes in the impairment of cell-mediated immunocompetence that has been observed repeatedly in patients with malignant gliomas.",

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T1 - Impaired immunocompetence in patients with malignant gliomas

T2 - The possible role of Tg-lymphocyte subpopulations

AU - Gerosa, M. A.

AU - Olivi, A.

AU - Rosenblum, M. L.

AU - Semenzato, G. P.

AU - Pezzutto, A.

PY - 1982

Y1 - 1982

N2 - T-lymphocyte subpopulations (Tg or 'suppressor cells' and Tm or 'helper cells') in the peripheral blood of 16 patients with malignant intracranial gliomas were analyzed. The number of TM-lymphocytes was very close to normal in both pre- and postoperative samples, whereas Tg-lymphocytes were significantly increased preoperatively (18.55 ± 1.11 vs. 12.72 ± 1.19, p < 0.001) and were still slightly higher than normal after operation and radiation treatment. These preliminary findings suggest a possible role of T-suppressor lymphocytes in the impairment of cell-mediated immunocompetence that has been observed repeatedly in patients with malignant gliomas.

AB - T-lymphocyte subpopulations (Tg or 'suppressor cells' and Tm or 'helper cells') in the peripheral blood of 16 patients with malignant intracranial gliomas were analyzed. The number of TM-lymphocytes was very close to normal in both pre- and postoperative samples, whereas Tg-lymphocytes were significantly increased preoperatively (18.55 ± 1.11 vs. 12.72 ± 1.19, p < 0.001) and were still slightly higher than normal after operation and radiation treatment. These preliminary findings suggest a possible role of T-suppressor lymphocytes in the impairment of cell-mediated immunocompetence that has been observed repeatedly in patients with malignant gliomas.

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Impaired immunocompetence in patients with malignant gliomas: The possible role of Tg-lymphocyte subpopulations

Abstract

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