Impaired immunocompetence in patients with malignant gliomas: The possible role of Tg-lymphocyte subpopulations

M. A. Gerosa, A. Olivi, M. L. Rosenblum, G. P. Semenzato, A. Pezzutto

Research output: Contribution to journalArticlepeer-review

Abstract

T-lymphocyte subpopulations (Tg or 'suppressor cells' and Tm or 'helper cells') in the peripheral blood of 16 patients with malignant intracranial gliomas were analyzed. The number of TM-lymphocytes was very close to normal in both pre- and postoperative samples, whereas Tg-lymphocytes were significantly increased preoperatively (18.55 ± 1.11 vs. 12.72 ± 1.19, p < 0.001) and were still slightly higher than normal after operation and radiation treatment. These preliminary findings suggest a possible role of T-suppressor lymphocytes in the impairment of cell-mediated immunocompetence that has been observed repeatedly in patients with malignant gliomas.

Original languageEnglish (US)
Pages (from-to)571-573
Number of pages3
JournalUnknown Journal
Volume10
Issue number5
DOIs
StatePublished - Jan 1 1982

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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