Impaired Glucose Metabolism in Obstructive Sleep Apnea

R. Akhouri, N. M. Punjabi, J. Polak

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Type 2 diabetes mellitus is one of the most rapidly increasing epidemics worldwide. The International Diabetes Federation estimates that the number of people with type 2 diabetes is expected to increase globally from 285 million in 2010 to 439 million in 2030, with the largest increases occurring in the United States, India, and China. Traditional risk factors for type 2 diabetes include age, race, family history, sedentary lifestyle, and obesity. Research over the last two decades has shown that obstructive sleep apnea (OSA) may also be associated with increased propensity for type 2 diabetes independent of other risk factors. OSA is a relatively common sleep disorder which is characterized by recurrent partial or complete collapse of the upper airway during sleep. The overall objective of the current article is to review the association between OSA and alterations in glucose metabolism, with a particular focus on underlying mechanisms.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Sleep
PublisherElsevier Inc.
Pages401-407
Number of pages7
ISBN (Electronic)9780123786111
ISBN (Print)9780123786104
DOIs
StatePublished - Jan 1 2013

Keywords

  • Diabetes mellitus
  • Gestational diabetes
  • Glucose
  • Hypothalamic-pituitary-adrenal system
  • Insulin
  • Obstructive sleep apnea
  • Sympathetic nervous system

ASJC Scopus subject areas

  • Medicine (miscellaneous)

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