Impaired fasting glucose and risk of cardiovascular disease in Korean men and women: The Korean Heart Study

Hong Kyu Kim, Chul Hee Kim, Eun Hee Kim, Sung Jin Bae, Jaewon Choe, Joong Yeol Park, Seong Wook Park, Young Duk Yun, Soo Jin Baek, Ye Jin Mok, Sun Ha Jee

Research output: Contribution to journalArticle

Abstract

OBJECTIVE-The relationship between impaired fasting glucose (IFG) and risk of cardiovascular disease (CVD) or ischemic heart disease (IHD) varies widely according to sex and ethnicity. We evaluated the relationship between IFG and CVD or IHD among Korean men and women. RESEARCH DESIGN AND METHODS-Atotal of 408,022 individuals who underwent voluntary private health examinations in 17 centers in South Korea were followed for 10 years. Data regarding CVD or IHD events were obtained from the Korean National Health Insurance database. IFG was categorized as grade 1 (fasting glucose 100-109 mg/dL) or grade 2 (110-125 mg/dL). RESULTS-Incidence rates of CVD (per 100,000 person-years) were 2,203 for diabetes. Age-adjustedhazard ratios (HRs)for CVD were 1.17(95%CI 1.13-1.20)for grade 1IFG, 1.30(1.24- 1.35) for grade 2 IFG, and 1.81 (1.75-1.86) for diabetes. The increased risk for women was similar to that of men. Age-adjusted HRs for IHD and ischemic stroke were also significantly increased for men and women with IFG and diabetes. After multivariate adjustment of conventional risk factors (hypertension, dyslipidemia, smoking, obesity, and family history of CVD), the overall risk of CVD was greatly attenuated in all categories. However, the HRs for IHD and ischemic stroke remained significantly increased in men for grade 2 IFG but not in women. CONCLUSIONS-In Korea, grade 2 IFG is associated with increased risk of IHD and ische-mic stroke, independent of other conventional risk factors, in men but not in women.

Original languageEnglish (US)
Pages (from-to)328-335
Number of pages8
JournalDiabetes care
Volume36
Issue number2
DOIs
StatePublished - Feb 1 2013
Externally publishedYes

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Fasting
Cardiovascular Diseases
Myocardial Ischemia
Glucose
Stroke
Social Adjustment
Republic of Korea
National Health Programs
Korea
Dyslipidemias
Research Design
Obesity
Smoking
Databases
Hypertension
Incidence
Health

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

Cite this

Kim, H. K., Kim, C. H., Kim, E. H., Bae, S. J., Choe, J., Park, J. Y., ... Jee, S. H. (2013). Impaired fasting glucose and risk of cardiovascular disease in Korean men and women: The Korean Heart Study. Diabetes care, 36(2), 328-335. https://doi.org/10.2337/dc12-0587

Impaired fasting glucose and risk of cardiovascular disease in Korean men and women : The Korean Heart Study. / Kim, Hong Kyu; Kim, Chul Hee; Kim, Eun Hee; Bae, Sung Jin; Choe, Jaewon; Park, Joong Yeol; Park, Seong Wook; Yun, Young Duk; Baek, Soo Jin; Mok, Ye Jin; Jee, Sun Ha.

In: Diabetes care, Vol. 36, No. 2, 01.02.2013, p. 328-335.

Research output: Contribution to journalArticle

Kim, HK, Kim, CH, Kim, EH, Bae, SJ, Choe, J, Park, JY, Park, SW, Yun, YD, Baek, SJ, Mok, YJ & Jee, SH 2013, 'Impaired fasting glucose and risk of cardiovascular disease in Korean men and women: The Korean Heart Study', Diabetes care, vol. 36, no. 2, pp. 328-335. https://doi.org/10.2337/dc12-0587
Kim, Hong Kyu ; Kim, Chul Hee ; Kim, Eun Hee ; Bae, Sung Jin ; Choe, Jaewon ; Park, Joong Yeol ; Park, Seong Wook ; Yun, Young Duk ; Baek, Soo Jin ; Mok, Ye Jin ; Jee, Sun Ha. / Impaired fasting glucose and risk of cardiovascular disease in Korean men and women : The Korean Heart Study. In: Diabetes care. 2013 ; Vol. 36, No. 2. pp. 328-335.
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T1 - Impaired fasting glucose and risk of cardiovascular disease in Korean men and women

T2 - The Korean Heart Study

AU - Kim, Hong Kyu

AU - Kim, Chul Hee

AU - Kim, Eun Hee

AU - Bae, Sung Jin

AU - Choe, Jaewon

AU - Park, Joong Yeol

AU - Park, Seong Wook

AU - Yun, Young Duk

AU - Baek, Soo Jin

AU - Mok, Ye Jin

AU - Jee, Sun Ha

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N2 - OBJECTIVE-The relationship between impaired fasting glucose (IFG) and risk of cardiovascular disease (CVD) or ischemic heart disease (IHD) varies widely according to sex and ethnicity. We evaluated the relationship between IFG and CVD or IHD among Korean men and women. RESEARCH DESIGN AND METHODS-Atotal of 408,022 individuals who underwent voluntary private health examinations in 17 centers in South Korea were followed for 10 years. Data regarding CVD or IHD events were obtained from the Korean National Health Insurance database. IFG was categorized as grade 1 (fasting glucose 100-109 mg/dL) or grade 2 (110-125 mg/dL). RESULTS-Incidence rates of CVD (per 100,000 person-years) were 2,203 for diabetes. Age-adjustedhazard ratios (HRs)for CVD were 1.17(95%CI 1.13-1.20)for grade 1IFG, 1.30(1.24- 1.35) for grade 2 IFG, and 1.81 (1.75-1.86) for diabetes. The increased risk for women was similar to that of men. Age-adjusted HRs for IHD and ischemic stroke were also significantly increased for men and women with IFG and diabetes. After multivariate adjustment of conventional risk factors (hypertension, dyslipidemia, smoking, obesity, and family history of CVD), the overall risk of CVD was greatly attenuated in all categories. However, the HRs for IHD and ischemic stroke remained significantly increased in men for grade 2 IFG but not in women. CONCLUSIONS-In Korea, grade 2 IFG is associated with increased risk of IHD and ische-mic stroke, independent of other conventional risk factors, in men but not in women.

AB - OBJECTIVE-The relationship between impaired fasting glucose (IFG) and risk of cardiovascular disease (CVD) or ischemic heart disease (IHD) varies widely according to sex and ethnicity. We evaluated the relationship between IFG and CVD or IHD among Korean men and women. RESEARCH DESIGN AND METHODS-Atotal of 408,022 individuals who underwent voluntary private health examinations in 17 centers in South Korea were followed for 10 years. Data regarding CVD or IHD events were obtained from the Korean National Health Insurance database. IFG was categorized as grade 1 (fasting glucose 100-109 mg/dL) or grade 2 (110-125 mg/dL). RESULTS-Incidence rates of CVD (per 100,000 person-years) were 2,203 for diabetes. Age-adjustedhazard ratios (HRs)for CVD were 1.17(95%CI 1.13-1.20)for grade 1IFG, 1.30(1.24- 1.35) for grade 2 IFG, and 1.81 (1.75-1.86) for diabetes. The increased risk for women was similar to that of men. Age-adjusted HRs for IHD and ischemic stroke were also significantly increased for men and women with IFG and diabetes. After multivariate adjustment of conventional risk factors (hypertension, dyslipidemia, smoking, obesity, and family history of CVD), the overall risk of CVD was greatly attenuated in all categories. However, the HRs for IHD and ischemic stroke remained significantly increased in men for grade 2 IFG but not in women. CONCLUSIONS-In Korea, grade 2 IFG is associated with increased risk of IHD and ische-mic stroke, independent of other conventional risk factors, in men but not in women.

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