Impaired Endothelial Function in Adolescents with Type 1 Diabetes Mellitus

Farid H. Mahmud, Stan Van Uum, Nimira Kanji, Heather Thiessen Philbrook, Cheril L. Clarson

Research output: Contribution to journalArticle

Abstract

Objective: To evaluate the effect of a high-fat meal on endothelial function in adolescents with type 1 diabetes mellitus (T1D). Study design: Twenty-three children with T1D, aged 12 to 18 years, and age- and sex-matched healthy control subjects were assessed for baseline macronutrient intake, and endothelial function was measured both fasting and after a standardized fast-food, high-fat breakfast. Results: Endothelial function, assessed noninvasively by peripheral arterial tonometry, was impaired in the T1D group in the fasting state as compared with control subjects (T1D 1.78 ± 0.4, control subjects 2.06 ± 0.4, P = .02), and worsened postprandially in both groups (T1D 1.45 ± 0.3, control subjects 1.71 ± 0.3, P = .01). Both groups demonstrated significantly elevated triglyceride levels 3.5 hours after ingestion of the high-fat meal (T1D 114.8 ± 42.8 and control subjects 126.7 ± 54.9 mg/dL). Nutrient intake in both groups showed higher than recommended intakes of total fat, saturated fat, and cholesterol. Conclusions: Patients with T1D exhibited worse endothelial function both before and after a high-fat breakfast than their peers. This suggests that patients with T1D are at greater risk of vascular impairment after a high-fat meal, the cumulative effect of which may contribute to the higher atherosclerotic burden observed in T1D.

Original languageEnglish (US)
Pages (from-to)557-562
Number of pages6
JournalJournal of Pediatrics
Volume152
Issue number4
DOIs
StatePublished - Apr 1 2008
Externally publishedYes

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Type 1 Diabetes Mellitus
Fats
Meals
Breakfast
Fasting
Fast Foods
Manometry
Blood Vessels
Healthy Volunteers
Triglycerides
Eating
Cholesterol
Food

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Impaired Endothelial Function in Adolescents with Type 1 Diabetes Mellitus. / Mahmud, Farid H.; Van Uum, Stan; Kanji, Nimira; Thiessen Philbrook, Heather; Clarson, Cheril L.

In: Journal of Pediatrics, Vol. 152, No. 4, 01.04.2008, p. 557-562.

Research output: Contribution to journalArticle

Mahmud, Farid H. ; Van Uum, Stan ; Kanji, Nimira ; Thiessen Philbrook, Heather ; Clarson, Cheril L. / Impaired Endothelial Function in Adolescents with Type 1 Diabetes Mellitus. In: Journal of Pediatrics. 2008 ; Vol. 152, No. 4. pp. 557-562.
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