Impaired Down-Regulation of Pituitary Dopamine Receptors by Estradiol in Aged Rats

Kazimierz Kochman; James A. Joseph; Marc R. Blackman; Carole A. Stagg; George S. Roth

doi:10.3181/00379727-192-42949

Impaired Down-Regulation of Pituitary Dopamine Receptors by Estradiol in Aged Rats

Kazimierz Kochman, James A. Joseph, Marc R. Blackman, Carole A. Stagg, George S. Roth

School of Medicine

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Administration of 17β-estradiol to mature (6–12 months) rats results in a more than 50% reduction in pituitary dopamine receptor concentrations, without affecting binding affinity. In contrast, when the same manipulation is performed on senescent (24–25 months) rats, negligible change in receptor concentration occurs. These results suggest that age-related increases in estrogen-stimulated prolactin release are not due to decreased dopaminergic inhibition at the receptor level.

Original language	English (US)
Pages (from-to)	23-26
Number of pages	4
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	192
Issue number	1
DOIs	https://doi.org/10.3181/00379727-192-42949
State	Published - Oct 1989

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

Access to Document

10.3181/00379727-192-42949

Cite this

@article{dc02ac7c0fc04a1e8ad08503abd6ee7d,

title = "Impaired Down-Regulation of Pituitary Dopamine Receptors by Estradiol in Aged Rats",

abstract = "Administration of 17β-estradiol to mature (6–12 months) rats results in a more than 50% reduction in pituitary dopamine receptor concentrations, without affecting binding affinity. In contrast, when the same manipulation is performed on senescent (24–25 months) rats, negligible change in receptor concentration occurs. These results suggest that age-related increases in estrogen-stimulated prolactin release are not due to decreased dopaminergic inhibition at the receptor level.",

author = "Kazimierz Kochman and Joseph, {James A.} and Blackman, {Marc R.} and Stagg, {Carole A.} and Roth, {George S.}",

year = "1989",

month = oct,

doi = "10.3181/00379727-192-42949",

language = "English (US)",

volume = "192",

pages = "23--26",

journal = "Proceedings of the Society for Experimental Biology and Medicine",

issn = "0037-9727",

publisher = "Society for Experimental Biology and Medicine",

number = "1",

}

TY - JOUR

T1 - Impaired Down-Regulation of Pituitary Dopamine Receptors by Estradiol in Aged Rats

AU - Kochman, Kazimierz

AU - Joseph, James A.

AU - Blackman, Marc R.

AU - Stagg, Carole A.

AU - Roth, George S.

PY - 1989/10

Y1 - 1989/10

N2 - Administration of 17β-estradiol to mature (6–12 months) rats results in a more than 50% reduction in pituitary dopamine receptor concentrations, without affecting binding affinity. In contrast, when the same manipulation is performed on senescent (24–25 months) rats, negligible change in receptor concentration occurs. These results suggest that age-related increases in estrogen-stimulated prolactin release are not due to decreased dopaminergic inhibition at the receptor level.

AB - Administration of 17β-estradiol to mature (6–12 months) rats results in a more than 50% reduction in pituitary dopamine receptor concentrations, without affecting binding affinity. In contrast, when the same manipulation is performed on senescent (24–25 months) rats, negligible change in receptor concentration occurs. These results suggest that age-related increases in estrogen-stimulated prolactin release are not due to decreased dopaminergic inhibition at the receptor level.

UR - http://www.scopus.com/inward/record.url?scp=0024466296&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024466296&partnerID=8YFLogxK

U2 - 10.3181/00379727-192-42949

DO - 10.3181/00379727-192-42949

M3 - Article

C2 - 2798435

AN - SCOPUS:0024466296

SN - 0037-9727

VL - 192

SP - 23

EP - 26

JO - Proceedings of the Society for Experimental Biology and Medicine

JF - Proceedings of the Society for Experimental Biology and Medicine

IS - 1

ER -

Impaired Down-Regulation of Pituitary Dopamine Receptors by Estradiol in Aged Rats

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this