Impaired Down-Regulation of Pituitary Dopamine Receptors by Estradiol in Aged Rats

Kazimierz Kochman, James A. Joseph, Marc R. Blackman, Carole A. Stagg, George S. Roth

Research output: Contribution to journalArticle

Abstract

Administration of 17β-estradiol to mature (6–12 months) rats results in a more than 50% reduction in pituitary dopamine receptor concentrations, without affecting binding affinity. In contrast, when the same manipulation is performed on senescent (24–25 months) rats, negligible change in receptor concentration occurs. These results suggest that age-related increases in estrogen-stimulated prolactin release are not due to decreased dopaminergic inhibition at the receptor level.

Original languageEnglish (US)
Pages (from-to)23-26
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine
Volume192
Issue number1
DOIs
StatePublished - Oct 1989

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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