Impaired chronotropic and vasodilator reserves limit exercise capacity in patients with heart failure and a preserved ejection fraction

Barry A. Borlaug, Vojtech Melenovsky, Stuart D. Russell, Kristy Kessler, Karel Pacak, Lewis Becker, David A Kass

Research output: Contribution to journalArticle

Abstract

BACKGROUND - Nearly half of patients with heart failure have a preserved ejection fraction (HFpEF). Symptoms of exercise intolerance and dyspnea are most often attributed to diastolic dysfunction; however, impaired systolic and/or arterial vasodilator reserve under stress could also play an important role. METHODS AND RESULTS - Patients with HFpEF (n=17) and control subjects without heart failure (n=19) generally matched for age, gender, hypertension, diabetes mellitus, obesity, and the presence of left ventricular hypertrophy underwent maximal-effort upright cycle ergometry with radionuclide ventriculography to determine rest and exercise cardiovascular function. Resting cardiovascular function was similar between the 2 groups. Both had limited exercise capacity, but this was more profoundly reduced in HFpEF patients (exercise duration 180±71 versus 455±184 seconds; peak oxygen consumption 9.0±3.4 versus 14.4±3.4 mL • kg • min; both P

Original languageEnglish (US)
Pages (from-to)2138-2147
Number of pages10
JournalCirculation
Volume114
Issue number20
DOIs
StatePublished - Nov 2006

Fingerprint

Vasodilator Agents
Heart Failure
Exercise
Radionuclide Ventriculography
Ergometry
Left Ventricular Hypertrophy
Oxygen Consumption
Dyspnea
Diabetes Mellitus
Obesity
Hypertension

Keywords

  • Diastole
  • Exercise
  • Heart failure
  • Heart rate
  • Hemodynamics
  • Nervous system, autonomic

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Impaired chronotropic and vasodilator reserves limit exercise capacity in patients with heart failure and a preserved ejection fraction. / Borlaug, Barry A.; Melenovsky, Vojtech; Russell, Stuart D.; Kessler, Kristy; Pacak, Karel; Becker, Lewis; Kass, David A.

In: Circulation, Vol. 114, No. 20, 11.2006, p. 2138-2147.

Research output: Contribution to journalArticle

Borlaug, Barry A. ; Melenovsky, Vojtech ; Russell, Stuart D. ; Kessler, Kristy ; Pacak, Karel ; Becker, Lewis ; Kass, David A. / Impaired chronotropic and vasodilator reserves limit exercise capacity in patients with heart failure and a preserved ejection fraction. In: Circulation. 2006 ; Vol. 114, No. 20. pp. 2138-2147.
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AU - Becker, Lewis

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