Impaired antibody response to Haemophilus Influenzae type b polysaccharide and low IgG2 and IgG4 concentrations in apache children

George R. Siber, Mathuram Santosham, G. Raymond Reid, Claudette Thompson, Janné Almeido-Hill, Andreas Morell, Gerda DeLange, Jeffrey K. Ketcham, Elaine H. Callahan

Research output: Contribution to journalArticle

Abstract

Background and Methods. Because Native American children are at much higher risk for invasive Haemophilus influenzae type b infection than white children, we compared the antibody responses to H. influenzae type b polysaccharide vaccine in healthy Apache and white children. Results. The concentrations of H. influenzae type b antibody after immunization with polysaccharide vaccine were approximately 10-fold lower in 24-month-old Apache children than in whites of a similar age (P

Original languageEnglish (US)
Pages (from-to)1387-1392
Number of pages6
JournalNew England Journal of Medicine
Volume323
Issue number20
StatePublished - Nov 15 1990

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Haemophilus influenzae type b
Antibody Formation
Polysaccharides
Immunoglobulin G
North American Indians
Immunization
Vaccines
Antibodies
Infection

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Siber, G. R., Santosham, M., Reid, G. R., Thompson, C., Almeido-Hill, J., Morell, A., ... Callahan, E. H. (1990). Impaired antibody response to Haemophilus Influenzae type b polysaccharide and low IgG2 and IgG4 concentrations in apache children. New England Journal of Medicine, 323(20), 1387-1392.

Impaired antibody response to Haemophilus Influenzae type b polysaccharide and low IgG2 and IgG4 concentrations in apache children. / Siber, George R.; Santosham, Mathuram; Reid, G. Raymond; Thompson, Claudette; Almeido-Hill, Janné; Morell, Andreas; DeLange, Gerda; Ketcham, Jeffrey K.; Callahan, Elaine H.

In: New England Journal of Medicine, Vol. 323, No. 20, 15.11.1990, p. 1387-1392.

Research output: Contribution to journalArticle

Siber, GR, Santosham, M, Reid, GR, Thompson, C, Almeido-Hill, J, Morell, A, DeLange, G, Ketcham, JK & Callahan, EH 1990, 'Impaired antibody response to Haemophilus Influenzae type b polysaccharide and low IgG2 and IgG4 concentrations in apache children', New England Journal of Medicine, vol. 323, no. 20, pp. 1387-1392.
Siber, George R. ; Santosham, Mathuram ; Reid, G. Raymond ; Thompson, Claudette ; Almeido-Hill, Janné ; Morell, Andreas ; DeLange, Gerda ; Ketcham, Jeffrey K. ; Callahan, Elaine H. / Impaired antibody response to Haemophilus Influenzae type b polysaccharide and low IgG2 and IgG4 concentrations in apache children. In: New England Journal of Medicine. 1990 ; Vol. 323, No. 20. pp. 1387-1392.
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