Impaired activation of oxygen consumption and blood flow in visual cortex of patients with mitochondrial encephalomyopathy

M. S. Vafaee, E. Meyer, A. Gjedde

Research output: Contribution to journalArticle

Abstract

A current hypothesis claims that an increase of blood flow is required for oxygen consumption to rise during neuronal excitation (activation). Chronic progressive external ophthalmoplegia is a mitochondrial disease associated with deletions of mtDNA or by point mutation of tRNA genes. We tested the hypothesis that the cerebral metabolic rate of oxygen (CMRO2) may not rise in this disorder if the accompanying cerebral blood flow increase is insufficient. Two patients with progressive external ophthalmoplegia were visually stimulated with a colored checkerboard pattern reversing as different frequencies. When stimulated, Patient 1 had a small increase of cerebral blood flow, while Patient 2 had no cerebral blood flow increase. In the visually active state, the patients had no significant change of CMRO2, while healthy subjects had a pronounced increase of CMRO2 in the pericalcarine visual cortex at 4 Hz and a further slight increase at 8 Hz during activation.

Original languageEnglish (US)
Pages (from-to)676-679
Number of pages4
JournalAnnals of Neurology
Volume48
Issue number4
DOIs
StatePublished - 2000
Externally publishedYes

Fingerprint

Mitochondrial Encephalomyopathies
Cerebrovascular Circulation
Visual Cortex
Oxygen Consumption
Chronic Progressive External Ophthalmoplegia
Mitochondrial Diseases
Transfer RNA
Mitochondrial DNA
Point Mutation
Healthy Volunteers
Oxygen
Genes

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Impaired activation of oxygen consumption and blood flow in visual cortex of patients with mitochondrial encephalomyopathy. / Vafaee, M. S.; Meyer, E.; Gjedde, A.

In: Annals of Neurology, Vol. 48, No. 4, 2000, p. 676-679.

Research output: Contribution to journalArticle

@article{76598974a8c54a6e89449c0b76628f9d,
title = "Impaired activation of oxygen consumption and blood flow in visual cortex of patients with mitochondrial encephalomyopathy",
abstract = "A current hypothesis claims that an increase of blood flow is required for oxygen consumption to rise during neuronal excitation (activation). Chronic progressive external ophthalmoplegia is a mitochondrial disease associated with deletions of mtDNA or by point mutation of tRNA genes. We tested the hypothesis that the cerebral metabolic rate of oxygen (CMRO2) may not rise in this disorder if the accompanying cerebral blood flow increase is insufficient. Two patients with progressive external ophthalmoplegia were visually stimulated with a colored checkerboard pattern reversing as different frequencies. When stimulated, Patient 1 had a small increase of cerebral blood flow, while Patient 2 had no cerebral blood flow increase. In the visually active state, the patients had no significant change of CMRO2, while healthy subjects had a pronounced increase of CMRO2 in the pericalcarine visual cortex at 4 Hz and a further slight increase at 8 Hz during activation.",
author = "Vafaee, {M. S.} and E. Meyer and A. Gjedde",
year = "2000",
doi = "10.1002/1531-8249(200010)48:4<676::AID-ANA18>3.0.CO;2-0",
language = "English (US)",
volume = "48",
pages = "676--679",
journal = "Annals of Neurology",
issn = "0364-5134",
publisher = "John Wiley and Sons Inc.",
number = "4",

}

TY - JOUR

T1 - Impaired activation of oxygen consumption and blood flow in visual cortex of patients with mitochondrial encephalomyopathy

AU - Vafaee, M. S.

AU - Meyer, E.

AU - Gjedde, A.

PY - 2000

Y1 - 2000

N2 - A current hypothesis claims that an increase of blood flow is required for oxygen consumption to rise during neuronal excitation (activation). Chronic progressive external ophthalmoplegia is a mitochondrial disease associated with deletions of mtDNA or by point mutation of tRNA genes. We tested the hypothesis that the cerebral metabolic rate of oxygen (CMRO2) may not rise in this disorder if the accompanying cerebral blood flow increase is insufficient. Two patients with progressive external ophthalmoplegia were visually stimulated with a colored checkerboard pattern reversing as different frequencies. When stimulated, Patient 1 had a small increase of cerebral blood flow, while Patient 2 had no cerebral blood flow increase. In the visually active state, the patients had no significant change of CMRO2, while healthy subjects had a pronounced increase of CMRO2 in the pericalcarine visual cortex at 4 Hz and a further slight increase at 8 Hz during activation.

AB - A current hypothesis claims that an increase of blood flow is required for oxygen consumption to rise during neuronal excitation (activation). Chronic progressive external ophthalmoplegia is a mitochondrial disease associated with deletions of mtDNA or by point mutation of tRNA genes. We tested the hypothesis that the cerebral metabolic rate of oxygen (CMRO2) may not rise in this disorder if the accompanying cerebral blood flow increase is insufficient. Two patients with progressive external ophthalmoplegia were visually stimulated with a colored checkerboard pattern reversing as different frequencies. When stimulated, Patient 1 had a small increase of cerebral blood flow, while Patient 2 had no cerebral blood flow increase. In the visually active state, the patients had no significant change of CMRO2, while healthy subjects had a pronounced increase of CMRO2 in the pericalcarine visual cortex at 4 Hz and a further slight increase at 8 Hz during activation.

UR - http://www.scopus.com/inward/record.url?scp=0033806496&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033806496&partnerID=8YFLogxK

U2 - 10.1002/1531-8249(200010)48:4<676::AID-ANA18>3.0.CO;2-0

DO - 10.1002/1531-8249(200010)48:4<676::AID-ANA18>3.0.CO;2-0

M3 - Article

C2 - 11026455

AN - SCOPUS:0033806496

VL - 48

SP - 676

EP - 679

JO - Annals of Neurology

JF - Annals of Neurology

SN - 0364-5134

IS - 4

ER -