Impacts of HIV infection and HAART use on quality of life

Chenglong Liu, David Ostrow, Roger Detels, Zheng Hu, Lisette Johnson, Lawrence Kingsley, Lisa Paula Jacobson

Research output: Contribution to journalArticle

Abstract

Background: Studies have shown the detrimental effect of HIV disease on quality of life (QOL). Changes in QOL related to the use of highly active antiretroviral therapy (HAART) have been inconsistent and it is unknown how QOL after HAART compares to pre-infection levels. Objective: The objective of this study was to determine the impacts of becoming HIV infected and using HAART on QOL within individuals followed in the Multicenter AIDS Cohort Study (MACS). Methods: Using the standard Medical Outcome Study SF-36 form, QOL data were collected pre-seroconversion, post-seroconversion but before HAART initiation, and after HAART initiation for 68 seroconverters. The QOL physical health summary score (PHS) and mental health summary score (MHS) were used as outcomes. The effects of HIV infection and HAART use on QOL summary scores were determined using random effects mixed linear models after controlling for possible confounders. The clinical significance of QOL change was assessed using the Cohen's effect size method. Results: Compared to pre-seroconversion values, the PHS decreased after seroconversion (mean difference (diff) = -1.62; 95% confidence interval (CI): [-3.20, -0.03]) and after HAART initiation (diff = -4.20; 95% CI: [-5.86, -2.54]) with small to medium effect sizes. The score remained significantly lower than prior to HIV infection (diff = -6.16; 95% CI: [-8.09, -4.23]) after being on HAART for more than 4 years. The MHS did not significantly differ upon seroconversion (diff = -1.16; 95% CI: [-3.32, 1.00]). After using HAART for more than 4 years, the MHS was significantly greater than prior to HIV infection (diff = 2.93; 95% CI: [0.31, 5.55]) with a small effect size. Conclusion: The QOL of participants has been dynamic over the HIV disease course. HIV infection deteriorated physical but not mental QOL. In this group, although the PHS following HAART has remained lower than that prior to infection, HAART has enhanced mental health functioning.

Original languageEnglish (US)
Pages (from-to)941-949
Number of pages9
JournalQuality of Life Research
Volume15
Issue number6
DOIs
StatePublished - Aug 2006

Fingerprint

Highly Active Antiretroviral Therapy
HIV Infections
Quality of Life
Confidence Intervals
Mental Health
HIV
Health
Infection
Linear Models
Acquired Immunodeficiency Syndrome
Cohort Studies
Outcome Assessment (Health Care)
Seroconversion

Keywords

  • HAART
  • HIV infection
  • Multicenter AIDS Cohort Study
  • Quality of life

ASJC Scopus subject areas

  • Rehabilitation
  • Nursing(all)

Cite this

Liu, C., Ostrow, D., Detels, R., Hu, Z., Johnson, L., Kingsley, L., & Jacobson, L. P. (2006). Impacts of HIV infection and HAART use on quality of life. Quality of Life Research, 15(6), 941-949. https://doi.org/10.1007/s11136-005-5913-x

Impacts of HIV infection and HAART use on quality of life. / Liu, Chenglong; Ostrow, David; Detels, Roger; Hu, Zheng; Johnson, Lisette; Kingsley, Lawrence; Jacobson, Lisa Paula.

In: Quality of Life Research, Vol. 15, No. 6, 08.2006, p. 941-949.

Research output: Contribution to journalArticle

Liu, C, Ostrow, D, Detels, R, Hu, Z, Johnson, L, Kingsley, L & Jacobson, LP 2006, 'Impacts of HIV infection and HAART use on quality of life', Quality of Life Research, vol. 15, no. 6, pp. 941-949. https://doi.org/10.1007/s11136-005-5913-x
Liu C, Ostrow D, Detels R, Hu Z, Johnson L, Kingsley L et al. Impacts of HIV infection and HAART use on quality of life. Quality of Life Research. 2006 Aug;15(6):941-949. https://doi.org/10.1007/s11136-005-5913-x
Liu, Chenglong ; Ostrow, David ; Detels, Roger ; Hu, Zheng ; Johnson, Lisette ; Kingsley, Lawrence ; Jacobson, Lisa Paula. / Impacts of HIV infection and HAART use on quality of life. In: Quality of Life Research. 2006 ; Vol. 15, No. 6. pp. 941-949.
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abstract = "Background: Studies have shown the detrimental effect of HIV disease on quality of life (QOL). Changes in QOL related to the use of highly active antiretroviral therapy (HAART) have been inconsistent and it is unknown how QOL after HAART compares to pre-infection levels. Objective: The objective of this study was to determine the impacts of becoming HIV infected and using HAART on QOL within individuals followed in the Multicenter AIDS Cohort Study (MACS). Methods: Using the standard Medical Outcome Study SF-36 form, QOL data were collected pre-seroconversion, post-seroconversion but before HAART initiation, and after HAART initiation for 68 seroconverters. The QOL physical health summary score (PHS) and mental health summary score (MHS) were used as outcomes. The effects of HIV infection and HAART use on QOL summary scores were determined using random effects mixed linear models after controlling for possible confounders. The clinical significance of QOL change was assessed using the Cohen's effect size method. Results: Compared to pre-seroconversion values, the PHS decreased after seroconversion (mean difference (diff) = -1.62; 95{\%} confidence interval (CI): [-3.20, -0.03]) and after HAART initiation (diff = -4.20; 95{\%} CI: [-5.86, -2.54]) with small to medium effect sizes. The score remained significantly lower than prior to HIV infection (diff = -6.16; 95{\%} CI: [-8.09, -4.23]) after being on HAART for more than 4 years. The MHS did not significantly differ upon seroconversion (diff = -1.16; 95{\%} CI: [-3.32, 1.00]). After using HAART for more than 4 years, the MHS was significantly greater than prior to HIV infection (diff = 2.93; 95{\%} CI: [0.31, 5.55]) with a small effect size. Conclusion: The QOL of participants has been dynamic over the HIV disease course. HIV infection deteriorated physical but not mental QOL. In this group, although the PHS following HAART has remained lower than that prior to infection, HAART has enhanced mental health functioning.",
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AU - Jacobson, Lisa Paula

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N2 - Background: Studies have shown the detrimental effect of HIV disease on quality of life (QOL). Changes in QOL related to the use of highly active antiretroviral therapy (HAART) have been inconsistent and it is unknown how QOL after HAART compares to pre-infection levels. Objective: The objective of this study was to determine the impacts of becoming HIV infected and using HAART on QOL within individuals followed in the Multicenter AIDS Cohort Study (MACS). Methods: Using the standard Medical Outcome Study SF-36 form, QOL data were collected pre-seroconversion, post-seroconversion but before HAART initiation, and after HAART initiation for 68 seroconverters. The QOL physical health summary score (PHS) and mental health summary score (MHS) were used as outcomes. The effects of HIV infection and HAART use on QOL summary scores were determined using random effects mixed linear models after controlling for possible confounders. The clinical significance of QOL change was assessed using the Cohen's effect size method. Results: Compared to pre-seroconversion values, the PHS decreased after seroconversion (mean difference (diff) = -1.62; 95% confidence interval (CI): [-3.20, -0.03]) and after HAART initiation (diff = -4.20; 95% CI: [-5.86, -2.54]) with small to medium effect sizes. The score remained significantly lower than prior to HIV infection (diff = -6.16; 95% CI: [-8.09, -4.23]) after being on HAART for more than 4 years. The MHS did not significantly differ upon seroconversion (diff = -1.16; 95% CI: [-3.32, 1.00]). After using HAART for more than 4 years, the MHS was significantly greater than prior to HIV infection (diff = 2.93; 95% CI: [0.31, 5.55]) with a small effect size. Conclusion: The QOL of participants has been dynamic over the HIV disease course. HIV infection deteriorated physical but not mental QOL. In this group, although the PHS following HAART has remained lower than that prior to infection, HAART has enhanced mental health functioning.

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