Impact of weight loss on ankle-brachial index and interartery blood pressures

the Look AHEAD Research Group

Research output: Contribution to journalArticle

Abstract

Objective To assess whether weight loss improves markers of peripheral artery disease and vascular stenosis. Methods The Action for Health in Diabetes randomized clinical trial compared intensive lifestyle intervention (ILI) for weight loss to a control condition of diabetes support and education (DSE) in overweight or obese adults with type 2 diabetes. Annual ankle and brachial blood pressures over four years were used to compute ankle-brachial indices (ABIs) and to assess interartery blood pressure differences in 5018 participants. Results ILI, compared to DSE, produced 7.8% (Year 1) to 3.6% (Year 4) greater weight losses. These did not affect prevalence of low (<0.90) ABI (3.60% in DSE versus 3.14% in ILI; P = 0.20) or elevated (>1.40) ABI (7.52% in DSE versus 7.59% in ILI: P = 0.90), but produced smaller mean (SE) maximum interartery systolic blood pressure differences among ankle sites [19.7 (0.2) mmHg for ILI versus 20.6 (0.2) mmHg for DSE (P < 0.001)] and between arms [5.8 (0.1) mmHg for ILI versus 6.1 (0.1) mmHg for DSE (P = 0.01)]. Conclusions Four years of intensive behavioral weight loss intervention did not significantly alter prevalence of abnormal ABI, however, it did reduce differences in systolic blood pressures among arterial sites.

Original languageEnglish (US)
Pages (from-to)1032-1041
Number of pages10
JournalObesity
Volume22
Issue number4
DOIs
StatePublished - Apr 1 2014

Fingerprint

Ankle Brachial Index
Weight Loss
Life Style
Blood Pressure
Education
Ankle
Arm
Peripheral Arterial Disease
Type 2 Diabetes Mellitus
Blood Vessels
Pathologic Constriction
Randomized Controlled Trials
Health

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

Cite this

Impact of weight loss on ankle-brachial index and interartery blood pressures. / the Look AHEAD Research Group.

In: Obesity, Vol. 22, No. 4, 01.04.2014, p. 1032-1041.

Research output: Contribution to journalArticle

the Look AHEAD Research Group. / Impact of weight loss on ankle-brachial index and interartery blood pressures. In: Obesity. 2014 ; Vol. 22, No. 4. pp. 1032-1041.
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abstract = "Objective To assess whether weight loss improves markers of peripheral artery disease and vascular stenosis. Methods The Action for Health in Diabetes randomized clinical trial compared intensive lifestyle intervention (ILI) for weight loss to a control condition of diabetes support and education (DSE) in overweight or obese adults with type 2 diabetes. Annual ankle and brachial blood pressures over four years were used to compute ankle-brachial indices (ABIs) and to assess interartery blood pressure differences in 5018 participants. Results ILI, compared to DSE, produced 7.8{\%} (Year 1) to 3.6{\%} (Year 4) greater weight losses. These did not affect prevalence of low (<0.90) ABI (3.60{\%} in DSE versus 3.14{\%} in ILI; P = 0.20) or elevated (>1.40) ABI (7.52{\%} in DSE versus 7.59{\%} in ILI: P = 0.90), but produced smaller mean (SE) maximum interartery systolic blood pressure differences among ankle sites [19.7 (0.2) mmHg for ILI versus 20.6 (0.2) mmHg for DSE (P < 0.001)] and between arms [5.8 (0.1) mmHg for ILI versus 6.1 (0.1) mmHg for DSE (P = 0.01)]. Conclusions Four years of intensive behavioral weight loss intervention did not significantly alter prevalence of abnormal ABI, however, it did reduce differences in systolic blood pressures among arterial sites.",
author = "{the Look AHEAD Research Group} and Espeland, {Mark A.} and Lewis, {Cora E.} and Judy Bahnson and Knowler, {William C.} and Regensteiner, {Judith G.} and Gaussoin, {Sarah A.} and Daniel Beavers and Johnson, {Karen C.} and Brancati, {Frederick L.} and Lee Swartz and Lawrence Cheskin and Cheskin, {Lawrence J} and Jeanne Clark and Kerry Stewart and Jean Arceci and Suzanne Ball and Jeanne Charleston and Charleston, {Jeanne B} and Mia Johnson and Joyce Lambert and Kathy Michalski and Dawn Jiggetts and Chanchai Sapun and Bray, {George A.} and Kristi Rau and Allison Strate and Greenway, {Frank L.} and Ryan, {Donna H.} and Donald Williamson and Brandi Armand and Jennifer Arceneaux and Amy Bachand and Michelle Begnaud and Betsy Berhard and Elizabeth Caderette and Barbara Cerniauskas and David Creel and Diane Crow and Crystal Duncan and Helen Guay and Carolyn Johnson and Nancy Kora and Kelly LaFleur and Kim Landry and Missy Lingle and Jennifer Perault and Cindy Puckett and Mandy Shipp and Marisa Smith and Elizabeth Tucker",
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AU - Knowler, William C.

AU - Regensteiner, Judith G.

AU - Gaussoin, Sarah A.

AU - Beavers, Daniel

AU - Johnson, Karen C.

AU - Brancati, Frederick L.

AU - Swartz, Lee

AU - Cheskin, Lawrence

AU - Cheskin, Lawrence J

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AU - Stewart, Kerry

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AU - Michalski, Kathy

AU - Jiggetts, Dawn

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AU - Bray, George A.

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AU - Strate, Allison

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AU - Arceneaux, Jennifer

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AU - Begnaud, Michelle

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AU - Guay, Helen

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AU - Landry, Kim

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N2 - Objective To assess whether weight loss improves markers of peripheral artery disease and vascular stenosis. Methods The Action for Health in Diabetes randomized clinical trial compared intensive lifestyle intervention (ILI) for weight loss to a control condition of diabetes support and education (DSE) in overweight or obese adults with type 2 diabetes. Annual ankle and brachial blood pressures over four years were used to compute ankle-brachial indices (ABIs) and to assess interartery blood pressure differences in 5018 participants. Results ILI, compared to DSE, produced 7.8% (Year 1) to 3.6% (Year 4) greater weight losses. These did not affect prevalence of low (<0.90) ABI (3.60% in DSE versus 3.14% in ILI; P = 0.20) or elevated (>1.40) ABI (7.52% in DSE versus 7.59% in ILI: P = 0.90), but produced smaller mean (SE) maximum interartery systolic blood pressure differences among ankle sites [19.7 (0.2) mmHg for ILI versus 20.6 (0.2) mmHg for DSE (P < 0.001)] and between arms [5.8 (0.1) mmHg for ILI versus 6.1 (0.1) mmHg for DSE (P = 0.01)]. Conclusions Four years of intensive behavioral weight loss intervention did not significantly alter prevalence of abnormal ABI, however, it did reduce differences in systolic blood pressures among arterial sites.

AB - Objective To assess whether weight loss improves markers of peripheral artery disease and vascular stenosis. Methods The Action for Health in Diabetes randomized clinical trial compared intensive lifestyle intervention (ILI) for weight loss to a control condition of diabetes support and education (DSE) in overweight or obese adults with type 2 diabetes. Annual ankle and brachial blood pressures over four years were used to compute ankle-brachial indices (ABIs) and to assess interartery blood pressure differences in 5018 participants. Results ILI, compared to DSE, produced 7.8% (Year 1) to 3.6% (Year 4) greater weight losses. These did not affect prevalence of low (<0.90) ABI (3.60% in DSE versus 3.14% in ILI; P = 0.20) or elevated (>1.40) ABI (7.52% in DSE versus 7.59% in ILI: P = 0.90), but produced smaller mean (SE) maximum interartery systolic blood pressure differences among ankle sites [19.7 (0.2) mmHg for ILI versus 20.6 (0.2) mmHg for DSE (P < 0.001)] and between arms [5.8 (0.1) mmHg for ILI versus 6.1 (0.1) mmHg for DSE (P = 0.01)]. Conclusions Four years of intensive behavioral weight loss intervention did not significantly alter prevalence of abnormal ABI, however, it did reduce differences in systolic blood pressures among arterial sites.

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