Impact of vitamin a supplementation on hematological indicators of iron metabolism and protein status in children

Richard D. Semba, M. P.H. Muhilal, Keith P. West, Marcy Winget, Gantira Natadisastra, Alan Scott, Alfred Sommer

Research output: Contribution to journalArticlepeer-review

Abstract

A randomized, double-masked, placebo-controlled, clinical trial of 236 preschool children, age 3-6, in West Java, Indonesia, was carried out to assess the impact of vitamin A supplementation on hematological indicators of iron metabolism and nutritional status. Clinically normal children (n=118) were matched by age and sex with xerophthalmic children (n=118) and randomized to receive oral vitamin A, 60,000 μg retinol equivalent, or placebo, creating a total of four study groups. Vitamin A supplementation was associated with a large increase (14.9±15.6 μg/L) in plasma ferritin (p<0.0001), a moderate increase (30±34 mg/L) in plasma transthyretin (p<0.0001), and an increase in hemoglobin in children with low baseline hemoglobin (p<0.05). This study suggests that vitamin A supplementation helps mobilize hepatic stores of iron and may enhance hematopoiesis in children with vitamin A deficiency.

Original languageEnglish (US)
Pages (from-to)469-478
Number of pages10
JournalNutrition Research
Volume12
Issue number4-5
DOIs
StatePublished - 1992

Keywords

  • Ferritin
  • Hemoglobin
  • Iron
  • Transthyretin
  • Vitamin A
  • Xerophthalmia

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

Fingerprint Dive into the research topics of 'Impact of vitamin a supplementation on hematological indicators of iron metabolism and protein status in children'. Together they form a unique fingerprint.

Cite this