Impact of Treatment for Nasal Cavity Disorders on Sleep Quality: Systematic Review and Meta-analysis

Jacob Fried, Erick Yuen, Kathy Zhang, Andraia Li, Nicholas R. Rowan, Rodney J. Schlosser, Shaun A. Nguyen, David A. Gudis

Research output: Contribution to journalReview articlepeer-review

Abstract

Objective: To determine the impact of treatment for patients with nasal obstruction secondary to allergic rhinitis (AR) and nasal septal deviation (NSD) on sleep quality. Data Sources: Primary studies were identified though PubMed, Scopus, Cochrane Library, and Web of Science. Review Methods: A systematic review was performed by querying databases for articles published through August 2020. Studies were included that reported on objective sleep parameters (apnea-hypopnea index) and sinonasal and sleep-specific patient-reported outcome measures: Rhinoconjunctivitis Quality of Life Questionnaire, Nasal Obstruction Symptom Evaluation, Epworth Sleepiness Scale (EpSS), and Pittsburgh Sleep Quality Index (PSQI). Results: The database search yielded 1414 unique articles, of which 28 AR and 7 NSD studies were utilized for meta-analysis. A total of 9037 patients (8515 with AR, 522 with NSD) were identified with a mean age of 35.0 years (35.3 for AR, 34.0 for NSD). Treatment for AR and NSD significantly improved subjective sleep quality. For AR, the EpSS mean difference was −1.5 (95% CI, –2.4 to –0.5; P =.002) and for the PSQI, –1.7 (95% CI, –2.1 to –1.2; P <.00001). For NSD, the EpSS mean difference was −3.2 (95% CI, –4.2 to –2.2; P <.00001) and for the PSQI, –3.4 (95% CI, –6.1 to –0.6; P =.02). Conclusion: Subjective sleep quality significantly improved following treatment for AR and NSD. There were insufficient data to demonstrate that objective metrics of sleep quality similarly improved.

Original languageEnglish (US)
JournalOtolaryngology - Head and Neck Surgery (United States)
DOIs
StateAccepted/In press - 2021

Keywords

  • allergic rhinitis
  • meta-analysis
  • nasal obstruction
  • nose diseases
  • sleep

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology

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