Impact of Treatment Beyond Progression with Immune Checkpoint Blockade in Hodgkin Lymphoma

Reid W. Merryman, Nicole A. Carreau, Ranjana H. Advani, Michael A. Spinner, Alex F. Herrera, Robert Chen, Sarah Tomassetti, Radhakrishnan Ramchandren, Muhammad Hamid, Sarit Assouline, Raoul Santiago, Nina Wagner-Johnston, Suman Paul, Jakub Svoboda, Steven M. Bair, Stefan K. Barta, Yang Liu, Sunita Nathan, Reem Karmali, Madelyn BurkartPallawi Torka, Kevin A. David, Catherine Wei, Frederick Lansigan, Lukas Emery, Daniel Persky, Sonali M. Smith, James Godfrey, Julio Chavez, Jonathan B. Cohen, Andrea B. Troxel, Catherine Diefenbach, Philippe Armand

Research output: Contribution to journalArticlepeer-review

Abstract

Atypical response patterns following immune checkpoint blockade (ICB) in Hodgkin lymphoma (HL) led to the concept of continuation of treatment beyond progression (TBP); however, the longitudinal benefit of this approach is unclear. We therefore performed a retrospective analysis of 64 patients treated with ICB; 20 who received TBP (TBP cohort) and 44 who stopped ICB at initial progression (non-TBP cohort). The TBP cohort received ICB for a median of 4.7 months after initial progression and delayed subsequent treatment by a median of 6.6 months. Despite receiving more prior lines of therapy, the TBP cohort achieved longer progression-free survival with post-ICB treatment (median, 17.5 months vs. 6.1 months, p =.035) and longer time-to-subsequent treatment failure, defined as time from initial ICB progression to failure of subsequent treatment (median, 34.6 months vs. 9.9 months, p =.003). With the limitations of a retrospective study, these results support the clinical benefit of TBP with ICB for selected patients.

Original languageEnglish (US)
Pages (from-to)e993-e997
JournalOncologist
Volume25
Issue number6
DOIs
StatePublished - Jun 1 2020

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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