Impact of toxigenic clostridium difficile colonization on the risk of subsequent C. Difficile infection in intensive care unit patients

Sarah Tschudin-Sutter, Karen C Carroll, Pranita Tamma, Madeleine L. Sudekum, Reno Frei, Andreas F. Widmer, Brandon C. Ellis, John Bartlett, Trish M. Perl

Research output: Contribution to journalArticle

Abstract

background. Clostridium difficile infection (CDI) in hospitalized patients is generally attributed to the current stay, but recent studies reveal high C. difficile colonization rates on admission. objective. To determine the rate of colonization with toxigenic C. difficile among intensive care unit patients upon admission as well as acquired during hospitalization, and the risk of subsequent CDI. methods. Prospective cohort study from April 15 through July 8, 2013. Adults admitted to an intensive care unit within 48 hours of admission to the Johns Hopkins Hospital, Baltimore, Maryland, were screened for colonization with toxigenic C. difficile. The primary outcome was risk of developing CDI. results. Among 542 patients, 17 (3.1%) were colonized with toxigenic C. difficile on admission and an additional 3 patients were found to be colonized during hospitalization. Both colonization with toxigenic C. difficile on admission and colonization during hospitalization were associated with an increased risk for development of CDI (relative risk, 10.29 [95% CI, 2.24–47.40], P=.003; and 15.66 [4.01–61.08], P

Original languageEnglish (US)
Pages (from-to)1324-1329
Number of pages6
JournalInfection Control and Hospital Epidemiology
Volume36
Issue number11
DOIs
StatePublished - 2015

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Clostridium difficile
Intensive Care Units
Clostridium Infections
Infection
Hospitalization
Baltimore
Patient Admission
Cohort Studies
Prospective Studies

ASJC Scopus subject areas

  • Microbiology (medical)
  • Epidemiology
  • Infectious Diseases

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Impact of toxigenic clostridium difficile colonization on the risk of subsequent C. Difficile infection in intensive care unit patients. / Tschudin-Sutter, Sarah; Carroll, Karen C; Tamma, Pranita; Sudekum, Madeleine L.; Frei, Reno; Widmer, Andreas F.; Ellis, Brandon C.; Bartlett, John; Perl, Trish M.

In: Infection Control and Hospital Epidemiology, Vol. 36, No. 11, 2015, p. 1324-1329.

Research output: Contribution to journalArticle

Tschudin-Sutter, Sarah ; Carroll, Karen C ; Tamma, Pranita ; Sudekum, Madeleine L. ; Frei, Reno ; Widmer, Andreas F. ; Ellis, Brandon C. ; Bartlett, John ; Perl, Trish M. / Impact of toxigenic clostridium difficile colonization on the risk of subsequent C. Difficile infection in intensive care unit patients. In: Infection Control and Hospital Epidemiology. 2015 ; Vol. 36, No. 11. pp. 1324-1329.
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