TY - JOUR
T1 - Impact of Surgical Status, Loneliness, and Disability on Interleukin 6, C-Reactive Protein, Cortisol, and Estrogen in Females with Symptomatic Type I Chiari Malformation
AU - Garcia, Monica A.
AU - Li, Xuan
AU - Allen, Philip A.
AU - Delahanty, Douglas L.
AU - Eppelheimer, Maggie S.
AU - Houston, James R.
AU - Johnson, Dawn M.
AU - Loth, Frank
AU - Maleki, Jahangir
AU - Vorster, Sarel
AU - Luciano, Mark G.
N1 - Publisher Copyright:
© 2021, This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply.
PY - 2021/12
Y1 - 2021/12
N2 - Chiari malformation type I (CMI) provides an opportunity for examining possible moderators of allostatic load. CMI patients who had (n = 43) and had not (n = 19) undergone decompression surgery completed questionnaires regarding pain, disability, and loneliness, and provided serum samples for IL-6, CRP, estrogen, and free estradiol assays, and saliva samples to assess diurnal cortisol curves. ANOVAs examining surgical status (decompressed versus non-decompressed), loneliness (high vs. low), and disability (high vs. low) as independent variables and biomarker variables as dependent factors found that loneliness was associated with higher levels of cortisol, F(1, 37) = 4.91, p =.04, η2P =.11, and lower levels of estrogen, F(1, 36) = 7.29, p =.01, η2P =.17, but only in decompressed patients. Results highlight the possible impact of loneliness on biological stress responses and the need to intervene to reduce loneliness in patients with symptomatic CMI.
AB - Chiari malformation type I (CMI) provides an opportunity for examining possible moderators of allostatic load. CMI patients who had (n = 43) and had not (n = 19) undergone decompression surgery completed questionnaires regarding pain, disability, and loneliness, and provided serum samples for IL-6, CRP, estrogen, and free estradiol assays, and saliva samples to assess diurnal cortisol curves. ANOVAs examining surgical status (decompressed versus non-decompressed), loneliness (high vs. low), and disability (high vs. low) as independent variables and biomarker variables as dependent factors found that loneliness was associated with higher levels of cortisol, F(1, 37) = 4.91, p =.04, η2P =.11, and lower levels of estrogen, F(1, 36) = 7.29, p =.01, η2P =.17, but only in decompressed patients. Results highlight the possible impact of loneliness on biological stress responses and the need to intervene to reduce loneliness in patients with symptomatic CMI.
KW - C-Reactive Protein
KW - Chiari malformation
KW - Cortisol
KW - Estrogen
KW - Interleukin 6
KW - Loneliness
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U2 - 10.1007/s12311-021-01251-w
DO - 10.1007/s12311-021-01251-w
M3 - Article
C2 - 33677786
AN - SCOPUS:85102303481
SN - 1473-4222
VL - 20
SP - 872
EP - 886
JO - Cerebellum
JF - Cerebellum
IS - 6
ER -