Impact of supplementing newborn infants with vitamin A on early infant mortality: Community based randomised trial in southern India

Lakshmi Rahmathullah, James M. Tielsch, R. D. Thulasiraj, Joanne Katz, Christian Coles, Sheela Devi, Rajeesh John, Karthik Prakash, A. V. Sadanand, N. Edwin, C. Kamaraj

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To assess the impact of supplementing newborn infants with vitamin A on mortality at age 6 months. Design: Community based, randomised, double blind, placebo controlled trial. Setting: Two rural districts of Tamil Nadu, southern India. Participants: 11 619 newborn infants allocated 24 000 IU oral vitamin A or placebo on days 1 and 2 after delivery. Main outcome measure: Primary outcome measure was mortality at age 6 months. Results: Infants in the vitamin A group had a 22% reduction in total mortality (95% confidence interval 4% to 37%) compared with those in the placebo group. Vitamin A had an impact on mortality between two weeks and three months after treatment, with no additional impact after three months. Conclusion: Supplementing newborn infants with vitamin A can significantly reduce early infant mortality.

Original languageEnglish (US)
Pages (from-to)254-257
Number of pages4
JournalBritish medical journal
Volume327
Issue number7409
StatePublished - Aug 2 2003

ASJC Scopus subject areas

  • Medicine(all)

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