Impact of Structured Pathways for Postcardiac Arrest Care: A Systematic Review and Meta-Analysis

Christian Storm, Christoph Leithner, Alexander Krannich, Jose I. Suarez, Robert D. Stevens

Research output: Contribution to journalReview article

Abstract

Objectives: Recent research has demonstrated value in selected therapeutic and prognostic interventions delivered to patients following cardiac arrest. The aim of this work was to determine if the implementation of a structured care pathway, which combines different interventions, could improve outcomes in survivors of cardiac arrest. Data Sources: PubMed and review of citations in retrieved articles. Study Selection: Randomized trials and prospective observational studies conducted in adult cardiac arrest patients, which evaluated the impact on outcome of a structured care pathway, defined as an organized set of interventions designed specifically for postcardiac arrest patients. Data Extraction: Data collected included study characteristics and methodologic quality, populations enrolled, interventions that were part of the cardiac arrest structured care pathway, and outcomes. The principal outcome was favorable functional status defined as a Cerebral Performance Category score of 1-2 at or after hospital discharge. Data Synthesis: The systematic search retrieved 481 articles of which nine (total, 1,994 patients) were selected for systematic review, and six (1,422 patients) met criteria for meta-analysis. Interventions in the care pathways included early coronary angiography with or without percutaneous coronary intervention (eight studies), targeted temperature management (nine studies), and protocolized management in the ICU (seven studies). Neurologic prognostication was not a part of any of the structured pathways. Meta-analysis found significantly higher odds of achieving a favorable functional outcome in patients who were treated in a structured care pathway, when compared with standard care (odds ratio, 2.35; 95% CI, 1.46-3.81). Conclusions: Following cardiac arrest, patients treated in a structured care pathway may have a substantially higher likelihood of favorable functional outcome than those who receive standard care. These findings suggest benefit of a highly organized approach to postcardiac arrest care, in which a cluster of evidence-based interventions are delivered by a specialized interdisciplinary team. Given the overall low certainty of evidence, definitive recommendations will need confirmation in additional high-quality studies.

Original languageEnglish (US)
Pages (from-to)E710-E716
JournalCritical care medicine
Volume47
Issue number8
DOIs
StatePublished - Aug 1 2019

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Meta-Analysis
Heart Arrest
Information Storage and Retrieval
Percutaneous Coronary Intervention
Coronary Angiography
PubMed
Nervous System
Observational Studies
Survivors
Odds Ratio
Prospective Studies
Temperature
Research
Population

Keywords

  • cardiac arrest
  • care delivery
  • coronary intervention
  • targeted temperature management

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Impact of Structured Pathways for Postcardiac Arrest Care : A Systematic Review and Meta-Analysis. / Storm, Christian; Leithner, Christoph; Krannich, Alexander; Suarez, Jose I.; Stevens, Robert D.

In: Critical care medicine, Vol. 47, No. 8, 01.08.2019, p. E710-E716.

Research output: Contribution to journalReview article

Storm, Christian ; Leithner, Christoph ; Krannich, Alexander ; Suarez, Jose I. ; Stevens, Robert D. / Impact of Structured Pathways for Postcardiac Arrest Care : A Systematic Review and Meta-Analysis. In: Critical care medicine. 2019 ; Vol. 47, No. 8. pp. E710-E716.
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abstract = "Objectives: Recent research has demonstrated value in selected therapeutic and prognostic interventions delivered to patients following cardiac arrest. The aim of this work was to determine if the implementation of a structured care pathway, which combines different interventions, could improve outcomes in survivors of cardiac arrest. Data Sources: PubMed and review of citations in retrieved articles. Study Selection: Randomized trials and prospective observational studies conducted in adult cardiac arrest patients, which evaluated the impact on outcome of a structured care pathway, defined as an organized set of interventions designed specifically for postcardiac arrest patients. Data Extraction: Data collected included study characteristics and methodologic quality, populations enrolled, interventions that were part of the cardiac arrest structured care pathway, and outcomes. The principal outcome was favorable functional status defined as a Cerebral Performance Category score of 1-2 at or after hospital discharge. Data Synthesis: The systematic search retrieved 481 articles of which nine (total, 1,994 patients) were selected for systematic review, and six (1,422 patients) met criteria for meta-analysis. Interventions in the care pathways included early coronary angiography with or without percutaneous coronary intervention (eight studies), targeted temperature management (nine studies), and protocolized management in the ICU (seven studies). Neurologic prognostication was not a part of any of the structured pathways. Meta-analysis found significantly higher odds of achieving a favorable functional outcome in patients who were treated in a structured care pathway, when compared with standard care (odds ratio, 2.35; 95{\%} CI, 1.46-3.81). Conclusions: Following cardiac arrest, patients treated in a structured care pathway may have a substantially higher likelihood of favorable functional outcome than those who receive standard care. These findings suggest benefit of a highly organized approach to postcardiac arrest care, in which a cluster of evidence-based interventions are delivered by a specialized interdisciplinary team. Given the overall low certainty of evidence, definitive recommendations will need confirmation in additional high-quality studies.",
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