Impact of six-week viral load on mortality in HIV-infected zimbabwean infants

Kuda Mutasa, Robert Ntozini, Andrew Prendergast, Peter Iliff, Sandra Rukobo, Lawrence H. Moulton, Brian J. Ward, Jean H. Humphrey

Research output: Contribution to journalArticlepeer-review

Abstract

Among 453 untreated HIV-infected Zimbabwean infants, 6-week viral load was the only infant factor that independently predicted mortality. Infants with viral load ≥ 1.59 million copies/mL (cohort median) had 3-fold increased mortality through 6 months (hazard ratio 3.07 [95% confidence interval: 2.16, 4.38]; P < 0.001) and 2-fold increased mortality through 12 months (hazard ratio 2.03 [95% confidence interval: 1.41, 2.91]; P < 0.001], compared with infants with viral load below the median.

Original languageEnglish (US)
Pages (from-to)948-950
Number of pages3
JournalPediatric Infectious Disease Journal
Volume31
Issue number9
DOIs
StatePublished - Sep 2012

Keywords

  • HIV
  • disease progression
  • infants
  • mortality
  • viral load

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)
  • Infectious Diseases

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