TY - JOUR
T1 - Impact of Routine Endoscopic Skull Base Surgery on Subjective Olfaction and Gustation Outcomes
AU - Hura, Nanki
AU - Orlov, Cinthia P.
AU - Khalafallah, Adham M.
AU - Mukherjee, Debraj
AU - Rowan, Nicholas R.
N1 - Publisher Copyright:
© 2021 Congress of Neurological Surgeons 2021.
PY - 2021/9/1
Y1 - 2021/9/1
N2 - BACKGROUND: As endoscopic endonasal skull base surgery (EESBS) for sellar pathology has become routine, there is increasing awareness of quality-of-life (QOL) outcomes related to this approach. Similarly, there is a growing interest in postoperative chemosensory function, with notable emphasis on olfaction and the corresponding psychosocial implications of olfactory dysfunction. Meanwhile, there has been minimal direct investigation into gustatory outcomes, and the association between these 2 chemosensory functions remains poorly understood. OBJECTIVE: To investigate patient-reported chemosensory function and rhinologic-specific QOL following EESBS for routine sellar pathologies. METHODS: Comprehensive clinical characteristics and sinonasal QOL assessments, measured using Anterior Skull Base Nasal Inventory-12 (ASK Nasal-12), were collected from 46 patients undergoing EESBS for sellar pathology. RESULTS: Forty-six patients were included: 65.2% female, average age 52.8 yr (range: 27-89). The most common pathology was nonfunctioning pituitary adenoma (n = 28). Preoperative ASK Nasal-12 scores (mean = 0.81) demonstrated postoperative worsening at 2 wk (mean = 2.52, P <. 0001) and 1 mo (mean = 1.33, P =. 0031), with no difference at 3 mo postoperatively (mean = 0.89, P =. 92). Meanwhile, there was significant worsening of preoperative subjective smell (mean = 0.62) and taste function (mean = 0.42) at 2 wk (mean = 3.48, P <. 0001; mean = 2.69, P <. 0001) and 1 mo (mean = 2.40, P <. 0001; mean = 2.03, P <. 0001) postoperatively, which persisted at approximately 3 mo postoperatively (mean = 1.26, P =. 04; mean = 1.15, P =. 0059). CONCLUSION: Patients undergoing EESBS for sellar pathologies experience anticipated, temporary disruptions in sinonasal QOL but may have longer lasting perturbations in subjective olfaction and gustation. Given the increasing use of the endoscopic endonasal corridor, further investigation in postoperative chemosensory function is essential.
AB - BACKGROUND: As endoscopic endonasal skull base surgery (EESBS) for sellar pathology has become routine, there is increasing awareness of quality-of-life (QOL) outcomes related to this approach. Similarly, there is a growing interest in postoperative chemosensory function, with notable emphasis on olfaction and the corresponding psychosocial implications of olfactory dysfunction. Meanwhile, there has been minimal direct investigation into gustatory outcomes, and the association between these 2 chemosensory functions remains poorly understood. OBJECTIVE: To investigate patient-reported chemosensory function and rhinologic-specific QOL following EESBS for routine sellar pathologies. METHODS: Comprehensive clinical characteristics and sinonasal QOL assessments, measured using Anterior Skull Base Nasal Inventory-12 (ASK Nasal-12), were collected from 46 patients undergoing EESBS for sellar pathology. RESULTS: Forty-six patients were included: 65.2% female, average age 52.8 yr (range: 27-89). The most common pathology was nonfunctioning pituitary adenoma (n = 28). Preoperative ASK Nasal-12 scores (mean = 0.81) demonstrated postoperative worsening at 2 wk (mean = 2.52, P <. 0001) and 1 mo (mean = 1.33, P =. 0031), with no difference at 3 mo postoperatively (mean = 0.89, P =. 92). Meanwhile, there was significant worsening of preoperative subjective smell (mean = 0.62) and taste function (mean = 0.42) at 2 wk (mean = 3.48, P <. 0001; mean = 2.69, P <. 0001) and 1 mo (mean = 2.40, P <. 0001; mean = 2.03, P <. 0001) postoperatively, which persisted at approximately 3 mo postoperatively (mean = 1.26, P =. 04; mean = 1.15, P =. 0059). CONCLUSION: Patients undergoing EESBS for sellar pathologies experience anticipated, temporary disruptions in sinonasal QOL but may have longer lasting perturbations in subjective olfaction and gustation. Given the increasing use of the endoscopic endonasal corridor, further investigation in postoperative chemosensory function is essential.
KW - Endoscopy
KW - Gustation
KW - Olfaction
KW - Olfaction disorders
KW - Pituitary diseases
KW - Prospective studies
KW - Quality of life
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U2 - 10.1093/ons/opab137
DO - 10.1093/ons/opab137
M3 - Article
C2 - 33956975
AN - SCOPUS:85114322265
SN - 2332-4252
VL - 21
SP - 137
EP - 142
JO - Operative Neurosurgery
JF - Operative Neurosurgery
IS - 3
ER -