Impact of respiratory motion on the detection of small pulmonary nodules in SPECT imaging

M. S. Smyczynski, H. C. Gifford, A. Lehovich, J. E. McNamara, W. P. Segars, B. M.W. Tsui, M. A. King

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The objective of this investigation is to determine the impact of respiratory motion on the detection of small solitary pulmonary nodules (SPN) in single photon emission computed tomographic (SPECT) imaging. We have previously modeled the respiratory motion of SPN based on the change of location of anatomic structures within the lungs identified on breath-held CT images of volunteers acquired at two different stages of respiration. This information on respiratory motion within the lungs was combined with the end-expiration and time-averaged NCAT phantoms to allow the creation of source and attenuation maps for the normal background distribution of Tc-99m NeoTect. With the source and attenuation distribution thus defined, the SIMIND Monte Carlo program was used to produce SPECT projection data for the normal background and separately for each of 150 end-expiration and time-averaged simulated 1.0 cm tumors. Normal and tumor SPECT projection sets each containing one lesion were combined with a clinically realistic noise level and counts. These were reconstructed with RBI-EM using 1) no correction (NC), 2) attenuation correction (AC), 3) detector response correction (RC), and 4) attenuation correction, detector response correction, and scatter correction (ACRCSC). The post-reconstruction parameters of number of iterations and 3-D Gaussian filtering were optimized by human-observer studies. Comparison of lesion detection by human-observer LROC studies reveals that respiratory motion degrades tumor detection for all four reconstruction strategies, and that the magnitude of this effect is greatest for NC and RC, and least for AC_RC_SC. Additionally, the AC_RC_SC strategy results in the best detection of lesions.

Original languageEnglish (US)
Title of host publication2007 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS-MIC
Pages3241-3245
Number of pages5
DOIs
StatePublished - Dec 1 2007
Event2007 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS-MIC - Honolulu, HI, United States
Duration: Oct 27 2007Nov 3 2007

Publication series

NameIEEE Nuclear Science Symposium Conference Record
Volume5
ISSN (Print)1095-7863

Other

Other2007 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS-MIC
CountryUnited States
CityHonolulu, HI
Period10/27/0711/3/07

ASJC Scopus subject areas

  • Radiation
  • Nuclear and High Energy Physics
  • Radiology Nuclear Medicine and imaging

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    Smyczynski, M. S., Gifford, H. C., Lehovich, A., McNamara, J. E., Segars, W. P., Tsui, B. M. W., & King, M. A. (2007). Impact of respiratory motion on the detection of small pulmonary nodules in SPECT imaging. In 2007 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS-MIC (pp. 3241-3245). [4436830] (IEEE Nuclear Science Symposium Conference Record; Vol. 5). https://doi.org/10.1109/NSSMIC.2007.4436830