Abstract
Puberty is the defining biological process of adolescent development, yet its effects on fundamental properties of brain physiology such as cerebral blood flow (CBF) have never been investigated. Capitalizing on a sample of 922 youths ages 8-22 y imaged using arterial spin labeled MRI as part of the Philadelphia Neurodevelopmental Cohort, we studied normative developmental differences in cerebral perfusion in males and females, as well as specific associations between puberty and CBF. Males and females had conspicuously divergent nonlinear trajectories in CBF evolution with development as modeled by penalized splines. Seventeen brain regions, including hubs of the executive and default mode networks, showed a robust nonlinear age-by-sex interaction that surpassed Bonferroni correction. Notably, within these regions the decline in CBF was similar between males and females in early puberty and only diverged in midpuberty, with CBF actually increasing in females. Taken together, these results delineate sex-specific growth curves for CBF during youth and for the first time to our knowledge link such differential patterns of development to the effects of puberty.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 8643-8648 |
| Number of pages | 6 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Volume | 111 |
| Issue number | 23 |
| DOIs | |
| State | Published - Jun 10 2014 |
| Externally published | Yes |
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ASJC Scopus subject areas
- General
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Impact of puberty on the evolution of cerebral perfusion during adolescence. / Satterthwaite, Theodore D.; Shinohara, Russell T.; Wolf, Daniel H.; Hopson, Ryan D.; Elliott, Mark A.; Vandekar, Simon N.; Ruparel, Kosha; Calkins, Monica E.; Roalf, David R.; Gennatas, Efstathios D.; Jackson, Chad; Erus, Guray; Prabhakaran, Karthik; Davatzikos, Christos; Detre, John A.; Hakonarson, Hakon; Gur, Ruben C.; Gur, Raquel E.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, No. 23, 10.06.2014, p. 8643-8648.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Impact of puberty on the evolution of cerebral perfusion during adolescence
AU - Satterthwaite, Theodore D.
AU - Shinohara, Russell T.
AU - Wolf, Daniel H.
AU - Hopson, Ryan D.
AU - Elliott, Mark A.
AU - Vandekar, Simon N.
AU - Ruparel, Kosha
AU - Calkins, Monica E.
AU - Roalf, David R.
AU - Gennatas, Efstathios D.
AU - Jackson, Chad
AU - Erus, Guray
AU - Prabhakaran, Karthik
AU - Davatzikos, Christos
AU - Detre, John A.
AU - Hakonarson, Hakon
AU - Gur, Ruben C.
AU - Gur, Raquel E.
PY - 2014/6/10
Y1 - 2014/6/10
N2 - Puberty is the defining biological process of adolescent development, yet its effects on fundamental properties of brain physiology such as cerebral blood flow (CBF) have never been investigated. Capitalizing on a sample of 922 youths ages 8-22 y imaged using arterial spin labeled MRI as part of the Philadelphia Neurodevelopmental Cohort, we studied normative developmental differences in cerebral perfusion in males and females, as well as specific associations between puberty and CBF. Males and females had conspicuously divergent nonlinear trajectories in CBF evolution with development as modeled by penalized splines. Seventeen brain regions, including hubs of the executive and default mode networks, showed a robust nonlinear age-by-sex interaction that surpassed Bonferroni correction. Notably, within these regions the decline in CBF was similar between males and females in early puberty and only diverged in midpuberty, with CBF actually increasing in females. Taken together, these results delineate sex-specific growth curves for CBF during youth and for the first time to our knowledge link such differential patterns of development to the effects of puberty.
AB - Puberty is the defining biological process of adolescent development, yet its effects on fundamental properties of brain physiology such as cerebral blood flow (CBF) have never been investigated. Capitalizing on a sample of 922 youths ages 8-22 y imaged using arterial spin labeled MRI as part of the Philadelphia Neurodevelopmental Cohort, we studied normative developmental differences in cerebral perfusion in males and females, as well as specific associations between puberty and CBF. Males and females had conspicuously divergent nonlinear trajectories in CBF evolution with development as modeled by penalized splines. Seventeen brain regions, including hubs of the executive and default mode networks, showed a robust nonlinear age-by-sex interaction that surpassed Bonferroni correction. Notably, within these regions the decline in CBF was similar between males and females in early puberty and only diverged in midpuberty, with CBF actually increasing in females. Taken together, these results delineate sex-specific growth curves for CBF during youth and for the first time to our knowledge link such differential patterns of development to the effects of puberty.
UR - http://www.scopus.com/inward/record.url?scp=84902171223&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84902171223&partnerID=8YFLogxK
U2 - 10.1073/pnas.1400178111
DO - 10.1073/pnas.1400178111
M3 - Article
C2 - 24912164
AN - SCOPUS:84902171223
VL - 111
SP - 8643
EP - 8648
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
SN - 0027-8424
IS - 23
ER -