Impact of puberty on the evolution of cerebral perfusion during adolescence

Theodore D. Satterthwaite, Russell T. Shinohara, Daniel H. Wolf, Ryan D. Hopson, Mark A. Elliott, Simon N. Vandekar, Kosha Ruparel, Monica E. Calkins, David R. Roalf, Efstathios D. Gennatas, Chad Jackson, Guray Erus, Karthik Prabhakaran, Christos Davatzikos, John A. Detre, Hakon Hakonarson, Ruben C. Gur, Raquel E. Gur

Research output: Contribution to journalArticle

Abstract

Puberty is the defining biological process of adolescent development, yet its effects on fundamental properties of brain physiology such as cerebral blood flow (CBF) have never been investigated. Capitalizing on a sample of 922 youths ages 8-22 y imaged using arterial spin labeled MRI as part of the Philadelphia Neurodevelopmental Cohort, we studied normative developmental differences in cerebral perfusion in males and females, as well as specific associations between puberty and CBF. Males and females had conspicuously divergent nonlinear trajectories in CBF evolution with development as modeled by penalized splines. Seventeen brain regions, including hubs of the executive and default mode networks, showed a robust nonlinear age-by-sex interaction that surpassed Bonferroni correction. Notably, within these regions the decline in CBF was similar between males and females in early puberty and only diverged in midpuberty, with CBF actually increasing in females. Taken together, these results delineate sex-specific growth curves for CBF during youth and for the first time to our knowledge link such differential patterns of development to the effects of puberty.

Original languageEnglish (US)
Pages (from-to)8643-8648
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume111
Issue number23
DOIs
StatePublished - Jun 10 2014
Externally publishedYes

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Cerebrovascular Circulation
Puberty
Perfusion
Biological Phenomena
Adolescent Development
Brain
Growth

ASJC Scopus subject areas

  • General

Cite this

Satterthwaite, T. D., Shinohara, R. T., Wolf, D. H., Hopson, R. D., Elliott, M. A., Vandekar, S. N., ... Gur, R. E. (2014). Impact of puberty on the evolution of cerebral perfusion during adolescence. Proceedings of the National Academy of Sciences of the United States of America, 111(23), 8643-8648. https://doi.org/10.1073/pnas.1400178111

Impact of puberty on the evolution of cerebral perfusion during adolescence. / Satterthwaite, Theodore D.; Shinohara, Russell T.; Wolf, Daniel H.; Hopson, Ryan D.; Elliott, Mark A.; Vandekar, Simon N.; Ruparel, Kosha; Calkins, Monica E.; Roalf, David R.; Gennatas, Efstathios D.; Jackson, Chad; Erus, Guray; Prabhakaran, Karthik; Davatzikos, Christos; Detre, John A.; Hakonarson, Hakon; Gur, Ruben C.; Gur, Raquel E.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, No. 23, 10.06.2014, p. 8643-8648.

Research output: Contribution to journalArticle

Satterthwaite, TD, Shinohara, RT, Wolf, DH, Hopson, RD, Elliott, MA, Vandekar, SN, Ruparel, K, Calkins, ME, Roalf, DR, Gennatas, ED, Jackson, C, Erus, G, Prabhakaran, K, Davatzikos, C, Detre, JA, Hakonarson, H, Gur, RC & Gur, RE 2014, 'Impact of puberty on the evolution of cerebral perfusion during adolescence', Proceedings of the National Academy of Sciences of the United States of America, vol. 111, no. 23, pp. 8643-8648. https://doi.org/10.1073/pnas.1400178111
Satterthwaite, Theodore D. ; Shinohara, Russell T. ; Wolf, Daniel H. ; Hopson, Ryan D. ; Elliott, Mark A. ; Vandekar, Simon N. ; Ruparel, Kosha ; Calkins, Monica E. ; Roalf, David R. ; Gennatas, Efstathios D. ; Jackson, Chad ; Erus, Guray ; Prabhakaran, Karthik ; Davatzikos, Christos ; Detre, John A. ; Hakonarson, Hakon ; Gur, Ruben C. ; Gur, Raquel E. / Impact of puberty on the evolution of cerebral perfusion during adolescence. In: Proceedings of the National Academy of Sciences of the United States of America. 2014 ; Vol. 111, No. 23. pp. 8643-8648.
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