Impact of pregnancy and lactation on GABA(A) receptor and central-type and peripheral-type benzodiazepine receptors

Ronit Weizman, Efrat Dagan, Solomon H. Snyder, Moshe Gavish

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of pregnancy and lactation on GABA(A) receptor and central- and peripheral-type benzodiazepine receptors (CBR and PBR, respectively) was studied in female Sprague-Dawley rats. Pregnancy was associated with increased CBR density (on day 19) in the hippocampus and with decreased [3H]Ro 15-1788-specific binding in the hypothalamus during pregnancy and lactation. A similar decrease in [3H]PK 11195-speciric binding was observed in the hypothalamus and pituitary. An increase in PBR density in the ovary and uterus was observed during pregnancy, while adrenal PBR density was down-regulated during pregnancy and lactation. It seems that the hormonal changes occurring during pregnancy and lactation play a role in the regulation of CBR and PBR in discrete tissues.

Original languageEnglish (US)
Pages (from-to)307-314
Number of pages8
JournalBrain research
Volume752
Issue number1-2
DOIs
StatePublished - Mar 28 1997

Keywords

  • GABA(A) receptor
  • central-type benzodiazepine receptor
  • lactation
  • peripheral-type benzodiazepine receptor
  • pregnancy
  • progesterone
  • prolactin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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